Kindling epileptogenesis in immature rats leads to persistent depressive behavior
Kindling epileptogenesis in immature rats leads to persistent depressive behavior
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DOI：
10.1016/j.yebeh.2007.02.001
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发表时间：
2007-05-01
影响因子：
2.6
通讯作者：
Sankar, Raman
中科院分区：
文献类型：
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作者：
Mazarati, Andrey;Shin, Don;Sankar, Raman
抑郁症是癫痫患者常见的合并症。多种生物学因素可能是癫痫相关抑郁症的基础。我们研究了点燃诱导的癫痫易感性的慢性增加是否伴随着抑郁症的行为症状。三周龄的Wistar大鼠进行快速点燃：84最初subconvulsant腹侧海马的电刺激，每5分钟提供一次，随后进行抑郁症特异性行为测试2周和4周后。与对照组相比，点燃的动物在强迫游泳试验中表现出持续的不动时间增加，并且失去了对无热量糖精的味觉偏好。最初对含热量蔗糖摄入的偏好丧失，随后在4周时增加了摄入量。在这两个时间点，动物表现出增强癫痫发作的敏感性测试刺激海马。我们的结论是，神经元的可塑性变化与点燃状态伴随着抑郁行为的发展。(C)2007爱思唯尔公司All rights reserved.
Depression is a frequent comorbidity in epilepsy patients. A variety of biological factors may underlie epilepsy-associated depression. We examined whether kindling-induced chronic increase in seizure susceptibility is accompanied by behavioral symptoms of depression. Three-week-old Wistar rats underwent rapid kindling: 84 initially subconvulsant electrical stimulations of ventral hippocampus delivered every 5 minutes, followed by depression-specific behavioral tests performed 2 and 4 weeks later. Kindled animals exhibited a sustained increase in immobility time in the forced swim test and the loss of taste preference toward calorie-free saccharin, as compared with controls. Initial loss of preference toward the intake of calorie-containing sucrose was followed by the increased consumption at 4 weeks. At both time points, animals exhibited enhanced seizure susceptibility on test stimulations of the hippocampus. We conclude that neuronal plastic changes associated with the kindling state are accompanied by the development of depressive behavior. (C) 2007 Elsevier Inc. All rights reserved.