Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder
Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder
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DOI：
10.1016/j.bbr.2006.01.009
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发表时间：
2006-05-15
影响因子：
2.7
通讯作者：
Sharma, T
中科院分区：
文献类型：
--
作者：
Barkataki, I;Kumari, V;Sharma, T
大脑异常与反社会人格障碍和精神分裂症有关，这两种精神障碍与暴力行为最有关联。结构磁共振成像用于研究整个大脑。小脑、颞叶、侧脑室、尾状核、壳核、丘脑、海马、杏仁核和前额叶、前运动区、感觉运动区、枕顶区，分别为13例反社会人格障碍患者、13例有暴力史的精神分裂症患者、15例无暴力史的精神分裂症患者和15例健康非暴力男性。与对照组相比，反社会人格障碍组表现出全脑体积和颞叶体积的减少以及壳核体积的增加。两个精神分裂症组，无论暴力史表现出侧脑室体积增加，而精神分裂症组暴力史表现出进一步的异常，包括减少全脑和海马体积和增加壳核大小。研究结果表明，反社会人格障碍患者以及精神分裂症和暴力史患者具有共同的神经异常，但也显示出神经解剖学差异。然而，它们达成表面上的共同立场的过程可能不同。反社会人格障碍患者普遍存在颞叶减少，暴力型精神分裂症患者海马减少，这一发现支持了该区域在调解暴力行为中的重要性。(C)2006 Elsevier B.V.保留所有权利。
Brain abnormalities are found in association with antisocial personality disorder and schizophrenia, the two mental disorders most implicated in violent behaviour. Structural magnetic resonance imaging was used to investigate the whole brain. cerebellum, temporal lobe, lateral ventricles, caudate nucleus, putamen, thalamus, hippocampus, amygdala and the prefrontal, pre-motor, sensorimotor, occipito-parietal regions in 13 men with antisocial personality disorder, 13 men with schizophrenia and a history of violence, 15 men with schizophrenia without violent history and 15 healthy non-violent men. Compared to controls, the antisocial personality disorder group displayed reductions in whole brain volume and temporal lobe as well as increases in putamen volume. Both schizophrenia groups regardless of violence history exhibited increased lateral ventricle volume, while the schizophrenia group with violent history showed further abnormalities including reduced whole brain and hippocampal volumes and increased putamen size. The findings suggest that individuals with antisocial personality disorder as well as those with schizophrenia and a history of violence have common neural abnormalities, but also show neuro-anatomical differences. The processes by which they came to apparently common ground may, however, differ. The finding of temporal lobe reductions prevalent among those with antisocial personality disorder and hippocampal reduction in the violent men with schizophrenia contributes support for the importance of this region in mediating violent behaviour. (C) 2006 Elsevier B.V. All rights reserved.