Adaptive changes in the rat dopaminergic transmission following repeated lithium administration
Adaptive changes in the rat dopaminergic transmission following repeated lithium administration
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DOI：
10.1007/bf01273357
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发表时间：
1996-01-01
影响因子：
3.3
通讯作者：
Wedzony, K
中科院分区：
文献类型：
--
作者：
Dziedzicka-Wasylewska, M;Mackowiak, M;Wedzony, K
本研究测定了大鼠纹状体(STR)和伏隔核(NAS)多巴胺(DA)及其代谢物的含量和DA受体D-2mRNA编码水平的变化，并与用锂时间有关。单次或亚慢性(3天)给锂，对DA和代谢物水平的影响不太一致；然而，给锂7天或14天后，终末DA释放显著减弱，这种影响在NAS更为明显。在同一时间治疗后，编码D-2受体的mRNA水平增加；这可能被解释为对长期服用锂后多巴胺能传递减少的适应性改变。
In the present study the alterations in the contents of dopamine (DA) and metabolites, as well as in the levels of mRNA coding for DA receptor D-2, were determined in the rat striatum (STR) and nucleus accumbens septi (NAS), in correlation with the duration of lithium administration. Single or subchronic (3 days) administration of lithium produced less consistent effects as far as the levels of DA and metabolites are concerned; however, following 7 or 14 days of lithium administration, the DA release from terminals was significantly attenuated and the effect was more pronounced in NAS. After the same time of treatment, the increase in the levels of mRNA coding for the D-2 receptor was increased; this might be interpreted as an adaptive change to the decreased dopaminergic transmission following the prolonged administration of lithium.