Prognostic clinical factors associated with remission and relapse in bullous pemphigoid
Prognostic clinical factors associated with remission and relapse in bullous pemphigoid
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DOI：
10.1111/jdv.13839
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发表时间：
2017-01-01
影响因子：
9.2
通讯作者：
Kim, S. -C.
中科院分区：
文献类型：
--
作者：
Lee, J. H.;Kim, T. H.;Kim, S. -C.
背景：大疱性类天疱疮（BP）缓解和复发的预后因素仍不确定。目的探讨韩国BP患者缓解和复发的相关临床因素。方法回顾性分析韩国首尔江南Severance医院1993 ~ 2014年诊断为BP的174例患者。结果174例患者中，131例（75.29%）在平均治疗时间393.69天后获得缓解。缓解的预后因素为年龄较大（>= 70岁）和无住院史。在131例获得缓解的患者中，40例（30.53%）在平均持续时间335.65天后复发。然而，通过多变量分析，没有统计学意义的因素预测复发。结论：年龄较大且无住院史的BP患者更易获得缓解。
Background Prognostic factors for remission and relapse of bullous pemphigoid (BP) remain uncertain.Objective To evaluate clinical factors associated with remission and relapse in Korean patients with BP.Methods A retrospective analysis was conducted of 174 patients diagnosed with BP between 1993 and 2014 at Gangnam Severance Hospital in Seoul, Korea.Results Of the 174 identified patients, 131 (75.29%) achieved remission after a mean treatment duration of 393.69 days. Prognostic factors for remission were older age (>= 70 years) and the absence of an admission history. Of 131 patients who achieved remission, 40 patients (30.53%) experienced relapse after a mean duration of 335.65 days. However, no statistically significant factors were predictive of relapse by multivariate analysis.Conclusions This study suggests BP patients who are older and have no admission history tend to achieve remission.