Prevalence of metabolic syndrome among patients with schizophrenia in Japan
Prevalence of metabolic syndrome among patients with schizophrenia in Japan
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DOI：
10.1016/j.schres.2010.08.030
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发表时间：
2010-11-01
影响因子：
4.5
通讯作者：
Kaneko, Sunao
中科院分区：
文献类型：
--
作者：
Sugawara, Norio;Yasui-Furukori, Norio;Kaneko, Sunao
目的：在亚洲人群中，代谢综合征（MetS）的标准与西方人群不同。本研究的目的是评估代谢综合征的患病率与精神分裂症或情感性精神障碍患者在Japanes.Methods：我们招募的患者（n = 1186），年龄54.8 +/- 14.8（平均值+/- SD）岁的DSM-IV诊断的精神分裂症或情感性精神障碍谁被接纳到七个精神病医院采用横断面设计。MetS患病率通过三种不同的定义进行评估，包括改编的国家胆固醇教育计划成人治疗小组（ATP III-A）。比较分析进行精神分裂症的主题和886名参与者从岩城健康促进项目2008年作为一般population.Results的代表：整体MetS患病率的基础上的ATP III-A的定义是27.5%，29.8%的男性和25.3%的女性患者。以年龄和体重指数为协变量的Logistic回归模型显示，在ATP III-A定义下，精神分裂症是MetS发展的一个重要独立因素（男性比值比= 2.00，女性为2.13）。MetS患病率患者和一般人群之间的差异观察那些60岁以下的age.Conclusions：精神分裂症或情感障碍患者在日本有较高的患病率MetS相比，一般人群，是最明显的那些60岁以下的年龄。应密切监测精神分裂症患者的代谢综合征，以尽量减少风险。(C)2010 Elsevier B. V.保留所有权利。
Aims: In an Asian population, the criteria for metabolic syndrome (MetS) are different from those for Western populations. The aim of this study was to assess the MetS prevalence among patients with schizophrenia or schizoaffective disorder in Japan.Methods: We recruited patients (n = 1186), aged 54.8 +/- 14.8 (mean +/- SD) years old with the DSM-IV diagnosis of schizophrenia or schizoaffective disorder who were admitted to seven psychiatric hospitals using a cross-sectional design. MetS prevalence was assessed by three different definitions, including the adapted National Cholesterol Education Program Adult Treatment Panel (ATP III-A). Comparative analysis was performed with schizophrenic subjects and 886 participants from the Iwaki Health Promotion Project 2008 as representative of general population.Results: The overall MetS prevalence based on the ATP Ill-A definition was 27.5%, with 29.8% in male and 25.3% in female patients. In a logistic regression model with age and body mass index as covariates, being schizophrenic was a significant independent factor (odds ratio = 2.00 for males, 2.13 for females) in the development of MetS under the ATP III-A definition. The difference of MetS prevalence between patients and the general population was observed for those under 60 years of age.Conclusions: Patients with schizophrenia or schizoaffective disorder in Japan had high prevalence of MetS compared to the general population, and was most apparent for those under 60 years of age. The MetS in schizophrenic patients should be carefully monitored to minimize the risks. (C) 2010 Elsevier B.V. All rights reserved.