Role of Articular Disc in Condylar Regeneration of the Mandible
Role of Articular Disc in Condylar Regeneration of the Mandible
复制标题
DOI：
10.1538/expanim.14-0015
复制
发表时间：
2014-10-01
影响因子：
2.4
通讯作者：
Tanimoto, Kotaro
中科院分区：
文献类型：
--
作者：
Hayashi, Hidetaka;Fujita, Tadashi;Tanimoto, Kotaro
颞下颌关节盘对下颌骨的生长发育起着重要的作用。功能矫治器诱导髁突再生，即使在髁突切除术后。本研究的目的是探讨关节盘的作用，在髁状突切除后，使用功能性矫治器在生长大鼠的髁状突再生。50只生长期大鼠行单侧髁突切除术，然后一半行椎间盘切除术。每组各取一半大鼠应用功能矫治器诱导髁突再生。4周和8周后，进行下颌骨的形态测量和组织学分析。两组髁突切除术后均有髁突再生。在髁状突切除+矫治器组中，髁状突的形状和软骨与正常髁状突相当。然而，在两个椎间盘切除组中，即使使用功能性矫治器，也没有观察到髁状突的再生。关节盘在受损髁突的再生中似乎是至关重要的，这表明关节盘的缺陷或损伤可能影响髁突的下颌生长和再生或修复。
The articular disc in the temporomandibular joint plays an important role in mandibular growth. Functional appliances induce regeneration of the condyle even after condylectomy. The aim of this study was to examine the role of the articular disc in regeneration of the condyle after unilateral condylectomy with use of a functional appliance in growing rats. Fifty growing rats were subjected to unilateral condylectomy and then half of them underwent discectomy. The functional appliance was applied to half of the rats in each group to induce regeneration of the condyle. Four and eight weeks later, morphometric and histologic analyses of the mandible were performed. Regeneration of the condyle was demonstrated in the two condylectomy groups. In the condylectomy+appliance group, the shape and cartilage of the condyle were equivalent to a normal condyle. However, regeneration of the condyle was not observed in the two discectomy groups even with the use of the functional appliance. The articular disc appears to be crucial in the regeneration of a damaged condyle, suggesting that defects or damage to the articular disc may influence mandibular growth and regeneration or repair of the condyle.