Differential Involvement of Glutamatergic Mechanisms in the Cognitive and Subjective Effects of Smoking
Differential Involvement of Glutamatergic Mechanisms in the Cognitive and Subjective Effects of Smoking
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DOI：
10.1038/npp.2008.50
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发表时间：
2009-01-01
影响因子：
7.6
通讯作者：
Duka, T.
中科院分区：
文献类型：
--
作者：
Jackson, A.;Nesic, J.;Duka, T.
越来越多的临床前证据表明谷氨酸参与尼古丁的行为作用。本研究的目的是研究N-甲基-D-天冬氨酸（NMDA）受体在人类吸烟的认知和主观影响中的作用。60名经常吸烟者参加了这项双盲安慰剂对照研究，研究了NMDA拮抗剂美金刚（40 mg）和尼古丁受体拮抗剂美卡拉明（10 mg）对吸烟诱导的持续注意力任务表现改善以及吸烟诱导的主观效应和渴望变化的影响。吸烟后主观评分的增加被美金刚逆转，但不是美加明。相比之下，吸烟对快速视觉信息处理任务的改善受到美加明的反对，但不是美金刚。吸烟减少了对香烟的渴望，但这两种药物都没有改变这种效果。我们的研究结果表明，吸烟的主观和认知行为可能有不同的参与机制。使用不同的配体进行进一步的研究是必要的，以充分表征谷氨酸的作用，吸烟行为的后果。
There is growing preclinical evidence for the involvement of glutamate in the behavioral actions of nicotine. The aim of this study, was to investigate the role of N-methyl-D-aspartate ( NMDA) receptors in the cognitive and subjective effects of smoking in humans. Sixty regular smokers took part in this double-blind placebo controlled study, that investigated the effect of the NMDA-antagonist memantine ( 40 mg) and the nicotinic-receptor antagonist mecamylamine ( 10 mg) on smoking-induced improvement in performance of a task of sustained attention and on smoking-induced changes in subjective effects and craving. Increases in subjective ratings of 'buzzed' following smoking were reversed by memantine, but not by mecamylamine. In contrast, improvement on a Rapid Visual Information Processing task by smoking was opposed by mecamylamine, but not by memantine. Smoking reduced craving for cigarettes, but neither drug altered this effect. Our results suggest that glutamatergic mechanisms may have differential involvement in the subjective and cognitive actions of smoking. Further investigations using different ligands are warranted to fully characterize the role of glutamate underlying the consequences of smoking behavior.