Retinal Point-Spread Function after Corneal Transplantation for Fuchs' Dystrophy
Retinal Point-Spread Function after Corneal Transplantation for Fuchs' Dystrophy
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DOI：
10.1167/iovs.10-5375
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发表时间：
2011-02-01
影响因子：
4.4
通讯作者：
Patel, Sanjay V.
中科院分区：
文献类型：
--
作者：
Seery, Loren S.;McLaren, Jay W.;Patel, Sanjay V.
目的。为了确定角膜移植治疗Fuchs‘s营养不良的效果和受者年龄对视网膜点扩散功能的大角度和小角度区域的影响。方法：对40只Fuchs’s营养不良的人工晶状体眼和30只正常人工晶状体眼进行了视网膜杂散光(大角度区域)和点扩散功能全宽/半最大强度(50%宽度，小角度区域)的测量。结果：DSEK或PK术后人工晶状体眼的50%宽度高于正常人工晶状体眼(P<；0.001)，但两者之间差异无统计学意义(P=0.36)。准分子激光原位角膜磨镶术后，HcVA与50%宽度相关(r=0.48，P=0.001，n=25)，与杂光相关(r=0.44，P=0.003，n=30)，而与杂光无相关性(r=0.77，P=0.003，n=8)。DSEK术后散光与受者年龄相关(r=0.001.6 7，P=0.39，n=8)，而与正常人工晶状体眼年龄无关(r=0.32，P=0.18，n=2 9)。结论：DSEK术后点扩散函数的小角域退化提示，像差是导致术后视力下降的原因之一。DSEK术后受体年龄较大的眼的光学特性较差可归因于保留的宿主角膜。(投资眼科VS科学。2011年；52：1003-1008)doi：10.1167/iovs.10-5375
PURPOSE. To determine the effect of corneal transplantation for Fuchs' dystrophy and of recipient age on the large-and small-angle domains of the retinal point-spread function.METHODS. Retinal stray light (large-angle domain) and the full-width-at-half-maximum intensity of the point-spread function (50% width, small-angle domain) were measured in 40 pseudophakic eyes after keratoplasty (Descemet stripping with endothelial keratoplasty [DSEK], 30 eyes; penetrating keratoplasty [PK], 10 eyes) for Fuchs' dystrophy and in 30 otherwise normal pseudophakic eyes. Correlations were assessed between the optical variables, high-contrast visual acuity (HCVA), and recipient age, and variables were compared between groups by using generalized estimating equation models.RESULTS. The 50% width was higher in pseudophakic eyes after DSEK or PK compared with otherwise normal pseudophakic eyes (P < 0.001) but did not differ between DSEK and PK (P = 0.36). After DSEK, HCVA correlated with the 50% width (r = 0.48, P < 0.001, n = 25) and stray light (r = 0.44, P = 0.01, n = 30), whereas after PK, HCVA correlated with the 50% width (r = 0.77, P = 0.003, n = 10) but not with stray light (r = 0.01, P = 0.98, n = 8). Stray light correlated with recipient age after DSEK (r = 0.67, P < 0.001, n = 30), but not after PK (r = 0.35, P = 0.39, n = 8,), and not with age of otherwise normal pseudophakic eyes (r = 0.32, P = 0.18, n = 29).CONCLUSIONS. The degradation of the small-angle domain of the point-spread function after DSEK suggests that aberrations contribute to decreased visual acuity after DSEK. The poorer optical properties of the eye with older recipient age after DSEK can be attributed to the retained host cornea. (Invest Ophthalmol Vis Sci. 2011; 52:1003-1008) DOI:10.1167/iovs.10-5375