Retinal blood flow levels measured by laser speckle flowgraphy in patients who received intravitreal bevacizumab injection for macular edema secondary to central retinal vein occlusion.
Retinal blood flow levels measured by laser speckle flowgraphy in patients who received intravitreal bevacizumab injection for macular edema secondary to central retinal vein occlusion.
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DOI：
10.1097/icb.0000000000000005
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Kitaoka, Takashi
中科院分区：
文献类型：
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作者：
Matsumoto, Makiko;Suzuma, Kiyoshi;Kitaoka, Takashi
目的：报告三名患者因视网膜中央静脉阻塞（CRVO）继发性黄斑水肿接受玻璃体内贝伐单抗注射（IVB）后通过激光散斑血流成像测量的视网膜血流水平。方法：检查三名接受 IVB（1.25 mg/0.05 mL）治疗的 CRVO 继发性黄斑水肿患者（3 眼）。血流的激光散斑血流分析基于视盘主要血管的平均模糊率（MBR）检查。使用Macular Cube 512 * 128扫描协议通过光学相干断层扫描测量中央视网膜厚度(CRT)。结果：在第一次IVB后，病例1表现出MBR增加和CRT减少。 4个月后，由于随后MBR下降和CRT增加，需要额外注射，这导致MBR增加和CRT下降，与第一次治疗后观察到的情况类似。随后，血流持续改善，无需额外进行 IVB。病例 2 的黄斑水肿复发导致 6 个月内又进行了 3 次 IVB。尽管注意到 MBR 增加和 CRT 下降，但每次 IVB 后 MBR 值往往会下降。在病例3中，黄斑水肿复发导致一年内额外进行了5次IVB。每次 IVB 后观察到患者持续 MBR 增加和 CRT 降低。通过激光散斑血流成像测量 MBR，我们可以预测 CRVO 的预后。结论：激光散斑血流成像证实了 3 名患者 IVB 后平均模糊率增加。尽管 CRVO 病理背景可能有所不同，但激光散斑血流成像可能有助于确定 CRVO 预后和评估治疗效果。
PURPOSE: To report retinal blood flow levels measured by Laser speckle flowgraphy in three patients after they received an intravitreal bevacizumab injection (IVB) for macular edema secondary to central retinal vein occlusion (CRVO).METHODS: Three patients (3 eyes) being treated with IVB (1.25 mg/0.05 mL) for secondary macular edema of CRVO were examined. Laser speckle flowgraphy analyses of the blood flow were based on the examinations of mean blur rate (MBR) at the major vessels of the optic disk. Central retinal thickness (CRT) was measured by optical coherence tomography using Macular Cube 512 * 128 scanning protocol.RESULTS: After the first IVB, Case 1 exhibited an increase in MBR and decrease in CRT. After 4 months, an additional injection was required because of a subsequent MBR decrease and CRT increase, which led to an increase in MBR and decrease in CRT similar to that observed after the first treatment. Subsequently, blood flow has continued to improve without additional IVB. Macular edema recurrence in Case 2 led to 3 further IVBs over a 6-month period. Although increases in MBR and decreases in CRT were noted, MBR values tended to decline after each IVB. In Case 3, macular edema recurrence led to 5 additional IVBs being carried out within a 1-year period. Continuous MBR increases and CRT decreases were observed in the patient after each IVB. By measuring MBR using laser speckle flowgraphy, we may predict the prognosis of CRVO.CONCLUSION: Mean blur rate increases after IVB were confirmed by laser speckle flowgraphy in three patients. Even though CRVO pathology backgrounds can vary, laser speckle flowgraphy may be useful in both determining the CRVO prognosis and in evaluating treatment efficacy.