A note on the inhibition of in vitro meiotic maturation of mammalian oocytes by dibutyryl cyclic AMP.
A note on the inhibition of in vitro meiotic maturation of mammalian oocytes by dibutyryl cyclic AMP.
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关于二丁酰环 AMP 抑制哺乳动物卵母细胞体外减数分裂成熟的注释。
DOI：
10.1002/jez.1402180224
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Goonan,WD
中科院分区：
文献类型：
--
作者：
Jagiello,G;Ducayen,MB;Goonan,WD
细胞遗传学数据表明，在二丁基环AMP （dbcAMP）存在的情况下，卵母细胞在体外成熟的反应存在物种差异。在25-750 μg/ml dbcAMP的存在下，母羊卵母细胞成熟被抑制在生发囊泡、MI和MII。母牛卵母细胞主要在MI和MII阶段受到相似浓度的影响，在这两个阶段只有750 μg/ml延迟金仓鼠卵母细胞。这些发现强调了这些哺乳动物与大鼠、小鼠或猪的卵母细胞反应之间的差异。
Cytogenetic data are presented which indicate species differences in the response of oocytes maturing in vitro in the presence of dibutyryl cyclic AMP (dbcAMP). Inhibition of ewe oocyte maturation was noted at germinal vesicle, MI, and MII in the presence of 25–750 μg/ml of dbcAMP. Cow oocytes were primarily affected at MI and MII by similar concentrations, and only 750 μg/ml delayed golden hamster oocytes at these stages. These findings highlight the variability between the responses of the oocytes of these mammals and the rat, mouse, or pig.