Handbook of epigenetics : the new molecular and medical genetics
Handbook of epigenetics : the new molecular and medical genetics
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发表时间：
2011
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通讯作者：
T. Tollefsbol
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作者：
T. Tollefsbol
表观遗传学被许多人认为是“新遗传学”，因为大量证据表明营养、环境和化学暴露等非遗传因素对基因表达的贡献。表观遗传学的影响是巨大的，包括组织/器官再生、X染色体失活、干细胞分化以及基因组印记和衰老。表观遗传学的畸变影响着许多已经有临床干预的疾病，并且许多针对癌症、免疫疾病、神经和代谢疾病以及印记疾病的新型表观遗传学疗法即将出现。这本由表观遗传学领域的领导者撰写的综合评论集为这个重要且不断发展的主题提供了广泛的视角。从分子机制和表观遗传学技术到人类疾病和临床表观遗传学的发现，将为那些对表观遗传学的基本基础到基于表观遗传学的疾病的治疗干预感兴趣的人们介绍科学的本质和应用。 * 参与分子研究以及临床和治疗应用的国际领先研究人员的贡献 * 将方法和生物学主题与基础和临床发现相结合 * 包括表观遗传学新主题的报道，例如朊病毒、表观遗传学对长期记忆的调节、表观遗传学的代谢方面以及神经元疾病的表观遗传学
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. * Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications * Integrates methods and biological topics with basic and clinical discoveries * Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders