The crystal structure of guanosine dihydrate and inosine dihydrate.
The crystal structure of guanosine dihydrate and inosine dihydrate.
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二水鸟苷和二水肌苷的晶体结构。
DOI：
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发表时间：
1970
期刊：
影响因子：
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通讯作者：
R. E. Marsh
中科院分区：
文献类型：
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作者：
U. Thewalt;C. Bugg;R. E. Marsh
鸟苷(C_(10)H_(13)N_5O_5)和肌苷(C_(10)H_(12)N_4O_5)的二水合物晶体几乎是同构的。它们是单斜晶系，空间群 P2_1，晶胞尺寸 ɑ = 17·518，b = 11·502，c = 6·658 A，β = 98·17°（鸟苷）和 ɑ = 17·573，b =11·278，c=6-654 A，β = 98·23°（肌苷）。有两个核苷
每个不对称单元有四个水分子。在自动衍射仪上收集数据；该结构通过 Patterson 和试错法求解，并细化至 R 指数约为 0·035。该结构的特点是嘌呤碱基之间形成氢键，形成平行于b的带状结构，并沿c平行堆叠嘌呤碱基；内相邻环之间的间隔
堆叠为3·3 A。不对称单元中的两个分子的糖苷C-N键和糖环褶皱的构象有很大不同。
Crystals of the dihydrates of guanosine (C_(10)H_(13)N_5O_5) and inosine (C_(10)H_(12)N_4O_5) are nearly isostructural. They are monoclinic, space group P2_1, with cell dimensions ɑ = 17·518, b = 11 ·502, c = 6·658 A, β = 98·17° (guanosine) and ɑ = 17·573, b =11·278, c=6-654 A, β = 98·23° (inosine). There are two nucleoside
molecules and four water molecules per asymmetric unit. Data were collected on an automated diffractometer; the structures were solved by Patterson and trial-and-error methods and refined to R indices of about 0·035. The structure features hydrogen bonding between purine bases to form ribbons parallel to b and parallel stacking of purine bases along c; the separation between adjacent rings within
a stack is 3·3 A. The conformations about the glycosidic C-N bond and the puckerings of the sugar rings arc quite different for the two molecules in the asymmetric unit.