Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery
Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery
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DOI：
10.1016/j.jconrel.2011.10.030
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发表时间：
2012-03-10
影响因子：
10.8
通讯作者：
Kissel, Thomas
中科院分区：
文献类型：
--
作者：
Beck-Broichsitter, Moritz;Schweiger, Christoph;Kissel, Thomas
许多研究已经解决了胶体颗粒的受控肺部药物递送特性。然而，只有很少的信息的潜力喷雾干燥制备亚微米颗粒。利用喷雾干燥的优点，可以优化亚微米颗粒的特性，以满足肺应用的要求。从有机聚（D，L-丙交酯-共-乙交酯）（PLGA）溶液制备亚微米颗粒，并从PLGA纳米混悬液中喷雾干燥复合颗粒。进料浓度以及喷雾筛孔直径影响所得颗粒尺寸。喷雾干燥后纳米颗粒几乎不受影响。两种颗粒的空气动力学特征揭示了适合在肺部深处沉积的气溶胶颗粒大小（
Numerous studies have addressed the controlled pulmonary drug delivery properties of colloidal particles. However, only scant information on the potential of spray-drying for submicron particle preparation is available. By exploiting the advantages of spray-drying, the characteristics of submicron particles can be optimized to meet the requirements necessary for lung application.Submicron particles were prepared from organic poly(D,L-lactide-co-glycolide) (PLGA) solutions, and composite particles were spray-dried from aqueous PLGA nanosuspensions. The feed concentration, as well as the spray-mesh diameter influenced the resulting particle sizes. Nanoparticles were virtually unaffected after spray-drying. The aerodynamic characteristics of both particle species revealed aerosol particle sizes suitable for deposition in the deep lungs (