Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives
Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives
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DOI：
10.1002/adma.201904106
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发表时间：
2019-12-03
影响因子：
29.4
通讯作者：
Yu, Chengzhong
中科院分区：
文献类型：
--
作者：
Wang, Yue;Yang, Yannan;Yu, Chengzhong
细菌感染是全球十大主要死亡原因之一，也是低收入国家最严重的杀手。抗生素的过度使用导致抗生素耐药性不断增加，对人类健康构成严重威胁。纳米技术的最新进展为解决细菌感染的挑战提供了新的机会，可以在不使用抗生素的情况下杀死细菌。介绍了先进纳米材料实现的无抗生素抗菌策略。纳米材料根据其作用模式进行分类：具有内在或光介导的杀菌特性的纳米材料，以及用作递送天然抗菌化合物的载体的其他纳米材料。特别关注的是抗菌机制和结构-性能关系。还介绍了采用这些无菌策略的实际抗菌应用。目前在这一领域的挑战和未来的前景提出，以刺激新技术和它们的翻译，以对抗细菌感染。
Bacterial infection is one of the top ten leading causes of death globally and the worst killer in low-income countries. The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. Antibiotic-free antibacterial strategies enabled by advanced nanomaterials are presented. Nanomaterials are classified on the basis of their mode of action: nanomaterials with intrinsic or light-mediated bactericidal properties and others that serve as vehicles for the delivery of natural antibacterial compounds. Specific attention is given to antibacterial mechanisms and the structure-performance relationship. Practical antibacterial applications employing these antibiotic-free strategies are also introduced. Current challenges in this field and future perspectives are presented to stimulate new technologies and their translation to fight against bacterial infection.