Short-term Effect of Fine Particulate Matter on Children's Hospital Admissions and Emergency Department Visits for Asthma: A Systematic Review and Meta-analysis.
Short-term Effect of Fine Particulate Matter on Children's Hospital Admissions and Emergency Department Visits for Asthma: A Systematic Review and Meta-analysis.
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DOI：
10.3961/jpmph.16.037
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发表时间：
2016-07-01
期刊：
影响因子：
--
通讯作者：
Choi, Won-Jun
中科院分区：
文献类型：
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作者：
Lim, Hyungryul;Kwon, Ho-Jang;Choi, Won-Jun
目的：尚未发表关于细颗粒物 (PM2.5) 对哮喘入院和急诊就诊的短期影响的针对儿童的综述和荟萃分析论文。我们计算了关于该主题的更精确的汇总效应估计，并根据先前研究中未考虑的研究特征的差异评估了效应大小的变化。 方法：两位作者于 2016 年 3 月各自独立检索了 PubMed 和 EMBASE 的相关研究。我们使用检索到的总结效应估计和 95% 置信区间 (CI) 以及所选研究的一些特征进行了随机效应荟萃分析和混合效应荟萃回归分析。 Egger 检验和漏斗图用于检查发表偏倚。所有分析均使用 R 版本 3.1.3 完成。结果：我们最终检索到 26 项时间序列和病例交叉设计研究，内容涉及 PM2.5 对哮喘儿童入院和急诊就诊的短期影响。在主要荟萃分析中，儿童因哮喘入院和急诊就诊与 PM2.5 短期增加 10 微克/立方米呈正相关（相对风险，1.048；95% CI，1.028 至 1.067；I2=95.7%）。我们还发现不同地区的影响系数不同；亚洲的数值估计低于北美或欧洲。结论：我们加强了 PM2.5 对哮喘儿童入院和急诊就诊的短期影响的证据。需要对北美和欧洲地区以外的其他地区进行进一步研究，以获得更普遍的证据。
OBJECTIVES: No children-specified review and meta-analysis paper about the short-term effect of fine particulate matter (PM2.5) on hospital admissions and emergency department visits for asthma has been published. We calculated more precise pooled effect estimates on this topic and evaluated the variation in effect size according to the differences in study characteristics not considered in previous studies.METHODS: Two authors each independently searched PubMed and EMBASE for relevant studies in March, 2016. We conducted random effect meta-analyses and mixed-effect meta-regression analyses using retrieved summary effect estimates and 95% confidence intervals (CIs) and some characteristics of selected studies. The Egger's test and funnel plot were used to check publication bias. All analyses were done using R version 3.1.3.RESULTS: We ultimately retrieved 26 time-series and case-crossover design studies about the short-term effect of PM2.5 on children's hospital admissions and emergency department visits for asthma. In the primary meta-analysis, children's hospital admissions and emergency department visits for asthma were positively associated with a short-term 10 mug/m3 increase in PM2.5 (relative risk, 1.048; 95% CI, 1.028 to 1.067; I2=95.7%). We also found different effect coefficients by region; the value in Asia was estimated to be lower than in North America or Europe.CONCLUSIONS: We strengthened the evidence on the short-term effect of PM2.5 on children's hospital admissions and emergency department visits for asthma. Further studies from other regions outside North America and Europe regions are needed for more generalizable evidence.