Plasma S-adenosylhomocysteine: A potential risk marker for cerebral venous thrombosis
Plasma S-adenosylhomocysteine: A potential risk marker for cerebral venous thrombosis
复制标题
DOI：
10.1016/j.cca.2016.04.024
复制
发表时间：
2016-07-01
影响因子：
5
通讯作者：
Christopher, Rita
中科院分区：
文献类型：
--
作者：
Bharatkumar, Venkata Pinnelli;Rudreshkumar, Kondapura Jayadevappa;Christopher, Rita
背景资料：尽管大量的研究表明高同型半胱氨酸血症与动脉和静脉血栓形成的风险增加有关，但关于S-腺苷高半胱氨酸（SAH）（同型半胱氨酸（Hcy）的代谢前体）作为脑静脉血栓形成（CVT）风险预测因子的作用的数据很少。我们估计了185名CVT患者和248名健康对照者的空腹血浆总高半胱氨酸（tHcy）、SAH和S-腺苷甲硫氨酸（SAM）浓度，结果：与对照组相比，冠心病组空腹tHcy、SAH和SAM均显著升高，且与对照组比较差异有统计学意义（P < 0. 05）。tHcy和SAH浓度升高分别与CVT风险增加4.54倍（95%CI，2.74-7.53）和35.77倍（95%CI，19.45-65.79）相关。受试者工作特征（ROC）曲线分析显示SAH的曲线下面积、敏感性和特异性均高于tHcy。此外，判别分析，以区分tHcy和SAH表明，SAH有一个显着较高的百分比分类，具有较低的Wilk的λ和较高的chi（2），相比tHCy.Conclusion：增加血浆SAH可能是一个更敏感的危险标志物CVT比血浆tHcy。(C)2016爱思唯尔B. V.保留所有权利。
Background: Despite a plethora of studies suggesting that hyperhomocysteinemia is associated with an increased risk for arterial and venous thrombosis, there is paucity of data on the role of the S-adenosylhomocysteine (SAH), the metabolic precursor of homocysteine (Hcy) as a risk predictor for cerebral venous thrombosis (CVT).Method: We estimated fasting plasma concentrations of total homocysteine (tHcy), SAH and S-adenosylmethionine (SAM), in 185 CVT patients and 248 healthy controls, by reverse-phase high performance liquid chromatography coupled with coulometric electrochemical detection.Results: Fasting tHcy, SAH and SAM were significantly higher in patients compared with controls. Increased tHcy and SAH concentrations were associated with 4.54-fold (95% CI, 2.74-7.53) and 35.77-fold (95% CI, 19.45-65.79) increase in risk for CVT, respectively. Receiver operating characteristic (ROC) curve analysis showed that the area under curve, sensitivity and specificity was higher for SAH compared to tHcy. Further, discriminant analysis to distinguish between tHcy and SAH showed that SAH had a significantly higher percentage classification, with lower Wilk's lambda and higher chi(2), compared to tHcy.Conclusion: Increased plasma SAH may be a more sensitive risk marker for CVT than plasma tHcy. (C) 2016 Elsevier B.V. All rights reserved.