Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons
Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons
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DOI：
10.1016/s0960-894x(02)00112-9
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发表时间：
2002-04-22
影响因子：
2.7
通讯作者：
Mitsumoto, Y
中科院分区：
文献类型：
--
作者：
Fukuyama, Y;Nakade, K;Mitsumoto, Y
Honokokoko.发现传统生药木兰科植物木兰在添加B27的无血清培养液中培养的皮层神经元，和厚朴酚能促进神经突起的生长。此外，在含N2的无血清培养液中加入和厚朴酚可显著增强神经元的存活和生长，其神经营养活性与浓度为10 μ M的40 ng/mL bFGF相当。(C)2002 Elseier Science Ltd.保留所有权利。
Honokiol. a main biphenyl neolignan of the traditional crude medicine, Magnoliae cortex, as found to show neurotrophic activity on the cultures of rat cortical neurons at concentration from 0.1 to 10 muM. In the cortical neurons cultured in serum-free medium Supplemented with B27, honokiol could promote neurite outgrowth. In addition, the survival and growth of neurons were significantly enhanced by adding honokiol to the primary cultures in serum-free medium supplemented with N2, Its neurotrophic activity was comparable to 40 ng mL(-1) of bFGF at concentration of 10 muM. (C) 2002 Elseier Science Ltd. All rights reserved.