REOVIRUS MESSENGER-RNA CONTAINS A METHYLATED, BLOCKED 5'-TERMINAL STRUCTURE - M7G(5')PPP(5')GMPCP-
REOVIRUS MESSENGER-RNA CONTAINS A METHYLATED, BLOCKED 5'-TERMINAL STRUCTURE - M7G(5')PPP(5')GMPCP-
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DOI：
10.1073/pnas.72.1.362
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发表时间：
1975-01-01
影响因子：
11.1
通讯作者：
SHATKIN, AJ
中科院分区：
文献类型：
--
作者：
FURUICHI, Y;MORGAN, M;SHATKIN, AJ
在s-腺苷甲硫氨酸存在下，呼肠孤病毒RNA聚合酶体外合成的mRNA含有被阻断、甲基化的5‘端，其结构为m-7G（5’）ppp(5')G-MpCp。讨论了这种新型5′-5′末端核苷酸连锁的功能意义和可能的形成机制。
Reovirus mRNA synthesized in vitro by the virus-associated RNA polymerase in the presence of S-adenosylmethionine contains blocked, methylated 5'-termini with the structure, m-7G(5')ppp(5')G-MpCp. The functional significance and possible mechanism of formation of this novel 5'-5' terminal nucleotide linkage are discussed.