Visceral Mycoses as a Cause of Severe HIV Infection and Death
Visceral Mycoses as a Cause of Severe HIV Infection and Death
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DOI：
10.1159/000515293
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发表时间：
2021-04-21
影响因子：
2.8
通讯作者：
Viktorova, Elena A.
中科院分区：
文献类型：
--
作者：
Azovtseva, Olga V.;Viktorova, Elena A.
近年来，在hiv感染者中，有越来越多的全身性真菌感染。这篇文章的目的是检查侵入性真菌病的频率在艾滋病毒感染者的时间，他们的紧急和/或计划入院的专科医院。方法：本研究的诊断方法包括体格检查、实验室检查、细菌学检查、免疫学检查、分子遗传学检查和放射影像学检查。该研究是在回顾性研究的伦理准则下进行的，没有披露个别患者的数据。结果：2016年至2018年，85例死于HIV感染史的HIV患者在诺夫哥罗德地区传染病医院接受了一系列临床和病理形态学检查。全身性真菌病常发生于呼吸系统，较少发生于脑部。它们的发病率很严重，与之相关的死亡率很高。在这项研究中，PCP是真菌引起的最常见的死亡原因。讨论/结论：综合多种诊断方法可诊断全身性真菌病。降低全身性真菌病死亡率的一个关键因素是早期诊断和强化抗菌治疗。
Introduction: In recent years, there has been an increase in the number of systemic fungal infections among HIV-infected individuals. The article aimed to examine the frequency of invasive mycoses among the HIV-infected patients at the time of their urgent and/or planned admission to a specialized hospital. Methods: The diagnostic methods used in this study involved physical examination, laboratory testing, bacteriological examination, immunological examination, molecular genetic testing, and radiological imaging. The study was conducted under the ethical guidelines for retrospective studies and does not disclose data on individual patients. Results: Between 2016 and 2018, 85 HIV patients who died with HIV history underwent a series of clinical and pathomorphological examinations at the Novgorod Regional Infectious Diseases Hospital. Systemic mycoses frequently occur in the respiratory system and less often in the brain. Their incidence is severe and the mortality rates associated with it are high. In this study, PCP was the most common cause of death provoked by mycoses. Discussion/Conclusion: Systemic fungal disease can be diagnosed through a combination of diagnostic methods. A crucial factor in the reduction of mortality rates for systemic mycosis is the early diagnosis and intensive antimicrobial therapy.