Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci
Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci
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DOI：
10.1038/86867
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发表时间：
2001-04-01
期刊：
影响因子：
30.8
通讯作者：
Harper, JI
中科院分区：
文献类型：
--
作者：
Cookson, WOCM;Ubhi, B;Harper, JI
我们进行了特应性皮炎（AD）的基因组筛查，并确定了染色体1q21，17q25和20p上与AD的连锁。这些区域与已知的银屑病位点密切对应，如先前在染色体3q21上鉴定的AD位点。结果表明，AD是受基因的影响，一般影响皮肤炎症和免疫。
We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.