Covert Representation of Second-Next Movement in the Pre-Supplementary Motor Area of Monkeys
Covert Representation of Second-Next Movement in the Pre-Supplementary Motor Area of Monkeys
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DOI：
10.1152/jn.90636.2008
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发表时间：
2009-04-01
影响因子：
2.5
通讯作者：
Tanji, Jun
中科院分区：
文献类型：
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作者：
Nakajima, Toshi;Hosaka, Ryosuke;Tanji, Jun
Nakajima T，Hosaka R，Mushiake H，Tanji J.猴子前补充运动区第二-下一步运动的显性表现。《神经生理学杂志》101：1883-1889,2009。2009年1月21日首次出版；DOI：10.1152/jn.90636.2008。我们试图从编码多个运动的角度分析内侧运动区[辅助运动区(SMA)和SMA前运动区]神经元运动前活动的性质。研究人员训练猴子做一系列的两种动作，其间有一段时间的延迟：旋后或前臂内旋。动作最初是由视觉信号指示的，但此后必须记住。虽然在这两个区域中发现了一种众所周知的代表即将到来的运动的运动前活动，但我们发现了一种意想不到的活动类型，它代表着在启动两个运动中的第一个运动之前的第二个下一个运动。通常在SMA前，这种对第二次运动的选择性活动在第一次运动开始之前达到顶峰，此后衰退，并在第二次运动开始时保持较低的幅度。这种类型的活动可以在启动第一运动的同时试探性地保存用于第二运动的信息。这些信息可能会被输入到另一组神经元中，这些神经元本身建立了计划第二次运动所需的准备活动。或者，该活动可以作为一种信号，以抑制第二个动作的运动指令的过早使用。
Nakajima T, Hosaka R, Mushiake H, Tanji J. Covert representation of second-next movement in the pre-supplementary motor area of monkeys. J Neurophysiol 101: 1883-1889, 2009. First published January 21, 2009; doi: 10.1152/jn.90636.2008. We attempted to analyze the nature of premovement activity of neurons in medial motor areas [supplementary motor area (SMA) and pre-SMA] from a perspective of coding multiple movements. Monkeys were trained to perform a series of two movements with an intervening delay: supination or pronation with either forearm. Movements were initially instructed with visual signals but had to be remembered thereafter. Although a well-known type of premovement activity representing the forthcoming movements was found in the two areas, we found an unexpected type of activity that represented a second-next movement before initiating the first of the two movements. Typically in the pre-SMA, such activity selective for the second-next movement peaked before the initiation of the first movement, decayed thereafter, and remained low in magnitude while initiating the second movement. This type of activity may tentatively hold information for the second movement while initiating the first. That information may be fed into another group of neurons that themselves build a preparatory activity required to plan the second movements. Alternatively, the activity could serve as a signal to inhibit a premature exertion of the motor command for the second movement.