Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving.
Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving.
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DOI：
10.1111/j.1369-1600.2010.00308.x
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发表时间：
2012-03
影响因子：
3.4
通讯作者：
Addolorato G
中科院分区：
文献类型：
--
作者：
Leggio L;Ferrulli A;Cardone S;Nesci A;Miceli A;Malandrino N;Capristo E;Canestrelli B;Monteleone P;Kenna GA;Swift RM;Addolorato G
动物研究表明，肠脑肽Ghrelin在酒精依赖(AD)的神经生物学中起着重要作用。人体研究表明酒精对胃促生长素水平的影响，以及酒精患者胃促生长素水平与酒精渴求之间的相关性。这项调查包括两项研究。研究1是一项为期12周的酒精依赖受试者研究，其中血浆Ghrelin测定被评估四次(T0-T3)，并与酒精摄入和渴望[宾夕法尼亚大学酒精渴望评分(PACS)和强迫性饮酒量表(OCDs)]相关。还进行了血清生长激素(GH)水平和营养/代谢状态的评估。研究2是一项先导性病例对照研究，旨在评估酒精依赖者Ghrelin基因(Arg51Gln和Leu72Met)的多态性。研究1显示，在整个样本中，Ghrelin水平没有显著差异，而在非禁欲和禁欲受试者之间，Ghrelin水平存在统计学差异。基线Ghrelin水平与T1时的PACS评分、T2和T3时的所有渴求评分(PACS、OCDs、强迫和强迫OCDs子分)呈显著正相关。在研究2中，虽然Leu72Met ghrelin基因多态在酒精依赖者中有较高的频率，但在健康对照组和酒精依赖者之间的分布没有统计学意义。这项研究表明，Ghrelin可能能够影响酒精寻求行为，如饮酒和渴望，代表着一个新的潜在的AD神经药理学靶点。
Animal studies suggest that the gut-brain peptide ghrelin plays an important role in the neurobiology of alcohol dependence (AD). Human studies show an effect of alcohol on ghrelin levels and a correlation between ghrelin levels and alcohol craving in alcoholics. This investigation consisted of two studies. Study 1 was a 12-week study with alcohol-dependent subjects, where plasma ghrelin determinations were assessed four times (T0-T3) and related to alcohol intake and craving [Penn Alcohol Craving Score (PACS) and Obsessive Compulsive Drinking Scale (OCDS)]. Serum growth hormone (GH) levels and assessment of the nutritional/metabolic status were also performed. Study 2 was a pilot case-control study to assess ghrelin gene polymorphisms (Arg51Gln and Leu72Met) in alcohol-dependent individuals. Study 1 showed no significant differences in ghrelin levels in the whole sample, while there was a statistical difference for ghrelin between non-abstinent and abstinent subjects. Baseline ghrelin levels were significantly and positively correlated with the PACS score at T1 and with all craving scores both at T2 and T3 (PACS, OCDS, obsessive and compulsive OCDS subscores). In Study 2, although there was a higher frequency of the Leu72Met ghrelin gene polymorphism in alcohol-dependent individuals, the distribution between healthy controls and alcohol dependent individuals was not statistically significant. This investigation suggests that ghrelin is potentially able to affect alcohol-seeking behaviors, such as alcohol drinking and craving, representing a new potential neuropharmacological target for AD.