Plant-derived anticancer agents
Plant-derived anticancer agents
复制标题
DOI：
10.1016/s0006-2952(96)00654-5
复制
发表时间：
1997-01-24
影响因子：
5.8
通讯作者：
Pezzuto, JM
中科院分区：
文献类型：
--
作者：
Pezzuto, JM
天然产物药物在药学服务中占有主导地位。这在抗肿瘤药物中尤其明显，例如紫杉醇（Taxol(R)）、长春新碱（Oncovin(R)）、长春瑞滨（Navelbine(R)）、替尼泊苷（Vumon(R)）和各种喜树碱的水溶性类似物（如喜树碱(R)）。发现诸如此类药物（即可能通过独特作用机制发挥作用的新型化学原型）的最有效方法是生物活性引导分馏，可以肯定的是，其他天然产物药物，其中一些应该对人类治疗有用，仍有待发现。对于结构复杂的天然产物药物的商业采购，与植物材料分离可能是最实用的方法。然而，随着组合化学和高通量筛选的出现，现在可以期待天然产物先导物取得更大的进展。虽然在相当程度上以天然产物为基础的全身药物治疗一直是药学保健的支柱，但疾病预防的逻辑是压倒性的。考虑到癌症的大流行病性质，提出了一项建议，以创造一种癌症化学预防药物配方，供一般民众广泛使用。癌症化学预防剂，其中许多是天然产物，能够预防或抑制癌变过程。与其他用于预防疾病的药物制剂一样，需要考虑对癌症化学预防制剂进行药物经济学分析，并且制剂的组成应随着时间的推移而改进。尽管如此，执行工作应立即开始。版权所有爱思唯尔科学有限公司
Natural product drugs play a dominant role in pharmaceutical care. This is especially obvious in the case of antitumor drugs, as exemplified by paclitaxel (Taxol(R)), vincristine (Oncovin(R)), vinorelbine (Navelbine(R)), teniposide (Vumon(R)), and various water-soluble analogs of camptothecin (e.g., Hycamtin(R)). The most efficient method of discovering drugs such as these (i.e. novel chemical prototypes that may function through unique mechanisms of action) is bioactivity-guided fractionation, and it is certain that additional natural product drugs, some of which should be useful for the treatment of humans, remain to be discovered. For the commercial procurement of structurally complex natural product drugs, isolation from plant material may be most practical. With the advent of combinatorial chemistry and high throughput screening, however, even greater progress may now be expected with natural product leads. While systemic drug therapy, to an appreciable extent based on natural products, has been the mainstay of pharmaceutical care, the logic of disease prevention is overwhelming. Bearing in mind the pandemic nature of cancer, a proposal is put forth to create a cancer chemoprevention drug formulation for utilization on a widespread basis by the general population. Cancer chemopreventive agents, many of which are natural products, are capable of preventing or inhibiting the process of carcinogenesis. As with other pharmaceutical agents useful for disease prevention, a pharmacoeconomic analysis of a cancer chemopreventive formulation would need to be considered, and the composition of the formulation should improve over time. Nonetheless, implementation should commence immediately. Copyright (C) 1996 Elsevier Science Inc.