Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study
Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study
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DOI：
10.1093/ajcn/75.5.880
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发表时间：
2002-05-01
影响因子：
7.1
通讯作者：
Witteman, JCM
中科院分区：
文献类型：
--
作者：
Geleijnse, JM;Launer, LJ;Witteman, JCM
背景：膳食类黄酮可以预防心血管疾病，但证据仍然相互矛盾。茶是黄酮类化合物在西方population.Objective的主要来源：茶和黄酮类化合物的摄入与事件心肌梗死的关联进行了检查，在一般Dutch population.Design：一个纵向分析进行了使用的数据从鹿特丹研究，一个人口为基础的研究，男性和女性年龄大于或等于55岁。在基线（1990-1993年）时，采用经验证的半定量食物频率问卷对饮食进行评估。该分析包括4807例无心肌梗死病史的受试者，随访至1997年12月31日。数据进行了分析，在一个考克斯回归模型，调整年龄，性别，体重指数，吸烟状况，包年的吸烟，教育水平，和每日摄入量的酒精，咖啡，多不饱和脂肪，饱和脂肪，纤维，维生素E，和总energy.Results：在5.6年的随访，共146首次心肌梗死发生，其中30人是致命的。每日摄入量>375 mL的饮茶者发生心肌梗死的相对危险度（RR：0.57; 95%CI：0.33，0.98）低于不饮茶者。与饮茶的负相关性在致死性事件（0.30; 0.09，0.94）中比在非致死性事件（0.68; 0.37，1.26）中更强。膳食黄酮类化合物（槲皮素+山奈酚+杨梅素）的摄入量显着呈负相关，仅与致命性心肌梗死（0.35，0.13，0.98）在上相比，较低的三分位数的intake.Conclusions：茶和黄酮类化合物的摄入量增加可能有助于缺血性心脏病的一级预防。
Background: Dietary flavonoids may protect against cardiovascular disease, but evidence is still conflicting. Tea is the major source of flavonoids in Western populations.Objective: The association of tea and flavonoid intake with incident myocardial infarction was examined in the general Dutch population.Design: A longitudinal analysis was performed with the use of data from the Rotterdam Study-a population-based study of men and women aged greater than or equal to55 y. Diet was assessed at baseline (1990-1993) with a validated semiquantitative food-frequency questionnaire. The analysis included 4807 subjects with no history of myocardial infarction, who were followed until 31 December 1997. Data were analyzed in a Cox regression model, with adjustment for age, sex, body mass index, smoking status, pack-years of cigarette smoking, education level, and daily intakes of alcohol, coffee, polyunsaturated fat, saturated fat, fiber, vitamin E, and total energy.Results: During 5.6 y of follow-up, a total of 146 first myocardial infarctions occurred, 30 of which were fatal. The relative risk (RR) of incident myocardial infarction was lower in tea drinkers with a daily intake >375 mL (RR: 0.57; 95% CI: 0.33, 0.98) than in nontea drinkers. The inverse association with tea drinking was stronger for fatal events (0.30; 0.09, 0.94) than for nonfatal events (0.68; 0.37, 1.26). The intake of dietary flavonoids (quercetin + kaempferol + myricetin) was significantly inversely associated only with fatal myocardial infarction (0.35, 0.13, 0.98) in upper compared with lower tertiles of intake.Conclusions: An increased intake of tea and flavonoids may contribute to the primary prevention of ischemic heart disease.