The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity
The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity
复制标题
骨髓源性抑制细胞在同种免疫和自身免疫中的作用和潜在治疗应用
DOI：
10.1155/2015/421927
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发表时间：
2015-05
影响因子：
4.6
通讯作者：
Qi Zhang
中科院分区：
文献类型：
--
作者：
Qi Zhang
髓源性抑制细胞（MDSCs）是由髓祖细胞和未成熟髓细胞组成的异质细胞群。它们已被确定为一种可能影响CD4+和CD8+ t细胞激活以负向调节免疫反应的细胞群，这使它们成为移植和自身免疫性疾病治疗的有吸引力的靶点。一些研究表明，MDSCs对同种异体和自身免疫反应有潜在的抑制作用。相反，MDSCs也被发现在不同的分化阶段，在病理情况下积累，不仅在肿瘤发展过程中，而且在各种炎症免疫反应、骨髓移植和一些自身免疫性疾病中。这些发现似乎是相互矛盾的。在这篇综述中，我们总结了MDSCs在不同移植和自身免疫性疾病模型中的作用，以及靶向这些细胞治疗益处的潜力。
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that consists of myeloid progenitor cells and immature myeloid cells. They have been identified as a cell population that may affect the activation of CD4+ and CD8+ T-cells to regulate the immune response negatively, which makes them attractive targets for the treatment of transplantation and autoimmune diseases. Several studies have suggested the potential suppressive effect of MDSCs on allo- and autoimmune responses. Conversely, MDSCs have also been found at various stages of differentiation, accumulating during pathological situations, not only during tumor development but also in a variety of inflammatory immune responses, bone marrow transplantation, and some autoimmune diseases. These findings appear to be contradictory. In this review, we summarize the roles of MDSCs in different transplantation and autoimmune diseases models as well as the potential to target these cells for therapeutic benefit.
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DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
C. Frey
通讯作者：
C. Frey
DOI：
10.1084/jem.20091474
发表时间：
2010-07-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Sander LE;Sackett SD;Dierssen U;Beraza N;Linke RP;Müller M;Blander JM;Tacke F;Trautwein C
通讯作者：
Trautwein C
源自小鼠诱导多能干细胞的调节性树突状细胞的产生和表征
影响因子：
4.6
作者：
Zhang Q;Fujino M;Iwasaki S;Hirano H;Cai S;Kitajima Y;Xu J;Li XK
通讯作者：
Li XK
影响因子：
5.4
作者：
Singh, Vibhuti;Mueller, Ulrike;Zoeller, Margot
通讯作者：
Zoeller, Margot
影响因子：
13.3
作者：
Lourenco, Elaine V.;Wong, Maida;Skaggs, Brian J.
通讯作者：
Skaggs, Brian J.