List-Mode PET Motion Correction Using Markerless Head Tracking: Proof-of-Concept With Scans of Human Subject
List-Mode PET Motion Correction Using Markerless Head Tracking: Proof-of-Concept With Scans of Human Subject
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DOI：
10.1109/tmi.2012.2219693
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发表时间：
2013-02-01
影响因子：
10.6
通讯作者：
Larsen, Rasmus
中科院分区：
文献类型：
--
作者：
Olesen, Oline V.;Sullivan, Jenna M.;Larsen, Rasmus
一种定制设计的无标记跟踪系统被证明适用于正电子发射断层扫描（PET）脑成像。精确的头部运动配准是PET成像精确运动校正的关键。应用PET脑成像的最先进的跟踪系统依赖于附着在患者头部的标记。标记附件是这些系统的主要弱点。一位健康的志愿者参加了一项吸烟研究，以成像多巴胺释放，在高分辨率研究断层扫描（HRRT） PET扫描仪上用C-11-racolopride扫描两次，持续2小时。头部运动独立测量，使用商用标记设备和提出的基于视觉的系统。利用检测到的运动，采用了一种单事件重构算法。获得了一个手控连续随机运动的幻体研究。运动是时变的，长漂移运动可达18毫米，规则的步进运动为1-6毫米。与没有MC相比，所评估的措施在运动校正图像方面明显更好。所演示的系统与商业集成系统一致。运动校正后的图像在小结构的对比度恢复方面得到了改善。
A custom designed markerless tracking system was demonstrated to be applicable for positron emission tomography (PET) brain imaging. Precise head motion registration is crucial for accurate motion correction (MC) in PET imaging. State-of-the-art tracking systems applied with PET brain imaging rely on markers attached to the patient's head. The marker attachment is the main weakness of these systems. A healthy volunteer participating in a cigarette smoking study to image dopamine release was scanned twice for 2 h with C-11-racolopride on the high resolution research tomograph (HRRT) PET scanner. Head motion was independently measured, with a commercial marker-based device and the proposed vision-based system. A list-mode event-by-event reconstruction algorithm using the detected motion was applied. A phantom study with hand-controlled continuous random motion was obtained. Motion was time-varying with long drift motions of up to 18 mm and regular step-wise motion of 1-6 mm. The evaluated measures were significantly better for motion-corrected images compared to no MC. The demonstrated system agreed with a commercial integrated system. Motion-corrected images were improved in contrast recovery of small structures.