Synthesis and anticonvulsant activity of racemic 2-amino-N-substituted succinimide derivatives.
Synthesis and anticonvulsant activity of racemic 2-amino-N-substituted succinimide derivatives.
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DOI：
10.1002/jps.2600700220
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发表时间：
1981-02
影响因子：
3.8
通讯作者：
A. Crider;T. M. Kolczynski;D. Miskell
中科院分区：
文献类型：
--
作者：
A. Crider;T. M. Kolczynski;D. Miskell
合成了几种(R，S)-2-氨基-N-取代琥珀酰亚胺类化合物，并用小鼠进行了抗惊厥和抗戊四氮惊厥实验。抗电击惊厥和抗戊四氮惊厥作用最强的化合物为(R，S)-N-苄基-2-(甲磺酰胺)琥珀酰亚胺。
Several derivatives of (R,S)-2-amino-N-substituted succinimides were synthetized and evaluated in mice against seizures produced by electroshock and pentylenetetrazol. The most active compound against both electroshock- and pentylenetetrazol-induced seizures was (R,S)-N-benzyl-2-(methanesulfamido)succinimide.