Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
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Tectochrysin 通过 FOXO/DAF-16 提高秀丽隐杆线虫的抗应激能力并延长其寿命
DOI：
10.1007/s10522-020-09884-w
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发表时间：
2020-06-06
期刊：
影响因子：
4.5
通讯作者：
Wu, Gui-Sheng
中科院分区：
文献类型：
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作者：
Lu, Min;Tan, Lin;Wu, Gui-Sheng
衰老与人类整体功能下降和各种与年龄相关的疾病风险增加有关。长春花素是一种黄酮类化合物，富含中药益智草，具有抗氧化、抗炎、抗癌、抗菌、止泻、保肝、神经保护等作用。因此，我们测试了tectochrysin是否对秀丽线虫(C.elegans)的衰老有影响。我们的研究结果表明，长春花素能延长线虫寿命21.0%，延缓与年龄相关的身体活动能力下降，提高抗高温应激能力和抗感染能力，并能保护线虫免受Aβ1-42的毒性。Tectochrysin不能延长daf-2、daf-16、Eat-2、AAK-2、SKN-1和HSF-1基因突变的寿命。长春花素可上调DAF-16调控基因的表达。通过tectochrysin延长寿命需要FOXO/DAF-16和HSF-1。总体而言，我们的发现表明，tectochrysin可能在延长寿命和与年龄相关的疾病方面具有潜在的作用。
Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Tectochrysin is a flavonoid compound and rich in a traditional Chinese Medicine Alpinia oxyphylla Miq., which has antioxidant, anti-inflammatory, anti-cancer, anti-bacterial, anti-diarrhea, hepatoprotective, and neuro-protective effects. Therefore, we tested if tectochrysin had an effect on aging in Caenorhabditis elegans (C. elegans). Our results showed that tectochrysin could extend the lifespan of C. elegans by up to 21.0%, delay the age-related decline of body movement, improve high temperature-stress resistance and anti-infection capacity, and protected worms against Aβ1-42-induced toxicity. Tectochrysin could not extend the lifespan of the mutants from genes daf-2, daf-16, eat-2, aak-2, skn-1, and hsf-1. Tectochrysin could increase the expression of DAF-16 regulated genes. The extension of lifespan by tectochrysin requires FOXO/DAF-16 and HSF-1. Overall, our findings suggest that tectochrysin may have a potential effect on extending lifespan and age-related diseases.