Hemodynamic and autonomic effects of smokeless tobacco in healthy young men.
Hemodynamic and autonomic effects of smokeless tobacco in healthy young men.
复制标题
无烟烟草对健康年轻男性的血流动力学和自主神经的影响。
DOI：
10.1016/j.jacc.2004.11.056
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Somers,VirendK
中科院分区：
文献类型：
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作者：
Wolk,Robert;Shamsuzzaman,AbuSM;Svatikova,Anna;Huyber,ChristineM;Huck,Corey;Narkiewicz,Krzysztof;Somers,VirendK
目的本研究的目的是调查无烟烟草对急性血流动力学和自主神经的影响。背景无烟烟草的使用正在增加。它对心血管的影响尚不清楚。方法采用随机、双盲、安慰剂对照、交叉设计和两个独立的实验阶段：安慰剂和烟草，对 16 名健康、男性、习惯性鼻烟使用者（年龄 22 ± 1 岁）进行了研究。测量了肌肉交感神经活动 (MSNA)、心电图、血压、小腿血流量、尼古丁和儿茶酚胺。结果鼻烟使血浆尼古丁从 2.8 ± 0.5 ng/ml 增加到 10.4 ± 1.1 ng/ml。平均血压增加 10 ± 1 mm Hg，心率增加 16 ± 2 次/分钟。烟草的外周血管阻力、MSNA 和去甲肾上腺素浓度没有变化，但肾上腺素增加了约 50%。结论口服鼻烟会增加心率、血压和肾上腺素。尽管血压升高，但 MSNA 或外周血管阻力并未降低。无烟烟草是一种强大的自主神经和血流动力学刺激。肾上腺髓质释放的儿茶酚胺可能有助于这种反应。
ObjectivesThe aim of this study was to investigate the acute hemodynamic and autonomic effects of smokeless tobacco.BackgroundSmokeless tobacco use is increasing. Its cardiovascular effects are not well understood.MethodsSixteen healthy, male, habitual snuff tobacco users (aged 22 ± 1 year) were studied, using a randomized, double-blind, placebo-controlled, crossover design with two separate experimental sessions: placebo and tobacco. Muscle sympathetic nerve activity (MSNA), electrocardiogram, blood pressure, calf blood flow, nicotine, and catecholamines were measured.ResultsSnuff tobacco increased plasma nicotine from 2.8 ± 0.5 ng/ml to 10.4 ± 1.1 ng/ml. Mean blood pressure increased by 10 ± 1 mm Hg, and heart rate increased by 16 ± 2 beats/min. Peripheral vascular resistance, MSNA, and norepinephrine concentration did not change with tobacco, but epinephrine increased by ∼50%.ConclusionsOral snuff tobacco increases heart rate, blood pressure, and epinephrine. Despite the increase in blood pressure, there is no decrease in either MSNA or peripheral vascular resistance. Smokeless tobacco is a powerful autonomic and hemodynamic stimulus. Catecholamine release from the adrenal medulla likely contributes to this response.