Aujeszky's disease virus: opportunities and challenges.
Aujeszky's disease virus: opportunities and challenges.
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DOI：
10.1051/vetres:2000111
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发表时间：
2000
影响因子：
4.4
通讯作者：
F. Zuckermann
中科院分区：
文献类型：
--
作者：
F. Zuckermann
自1902年被发现以来，奥杰斯基病（Aujeszky's disease，AD）已成为研究最透彻的猪病毒性疾病之一。病原体Aujeszky病病毒（ADV）是一种嗜神经性α疱疹病毒，在新生猪中产生致命的脑炎，在老年动物中产生较轻的综合征。在一些情况下，这种病毒已被用作测试案例，以检查猪的新疫苗概念，包括作为该领域使用的第一种转基因疫苗的荣誉。此外，对感染或接种该病毒的免疫应答的检查揭示了关于猪免疫系统功能的重要信息，包括猪体液和细胞免疫应答之间存在二分法的证据。本文综述了ADV作为新型疫苗开发的重要工具的研究进展，并为更好地了解猪对传染性病原体的免疫反应提供了信息。
Since its description in 1902, Aujeszky's disease (AD) has become one of the most thoroughly examined viral diseases of swine. The causative agent, Aujeszky's disease virus (ADV), is a neurotropic alphaherpesvirus that produces fatal encephalitis in newborn pigs and a milder syndrome in older animals. In several instances this virus has been used as a test case to examine novel vaccine concepts in swine, including the honor of being the first genetically modified vaccine used in the field. Furthermore, the examination of the immune response to infection or vaccination with this virus has revealed important information about the function of the porcine immune system, including evidence on the existence of a dichotomy between the humoral and cellular immune response in swine. This review presents a summary of research where ADV has been a valuable tool for the development of novel vaccines and has provided information to better understand the immune response of swine to infectious agents.