Three-phase CFD analytical modeling of blood flow
Three-phase CFD analytical modeling of blood flow
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DOI：
10.1016/j.medengphy.2006.12.004
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发表时间：
2008-01-01
影响因子：
2.2
通讯作者：
Hassanein, Ahmed
中科院分区：
文献类型：
--
作者：
Jung, Jonghwun;Hassanein, Ahmed
血细胞在动脉血流紊乱区域的行为对于了解动脉粥样硬化的发生有重要意义。然而，它们与红细胞和白细胞的分布还没有得到很好的研究和了解。我们使用了包括血浆、红细胞和白细胞的三相计算流体动力学方法来数值模拟这种流动状态下的局部血流动力学。该模型跟踪了血液集中悬浮剪切流中各相的壁面剪应力、相分布和流型。与其他计算方法不同，该方法不需要色散系数作为输入。非牛顿粘度模型适用于包括低切变率在内的广泛的血细胞生理范围。计算了扰动流区血细胞的迁移和分离，计算结果与已有的实验数据吻合较好。预测的较高白细胞浓度与相对较低的WSS相关，狭窄附近有较高的WSS。这种行为归因于脉动流中白细胞与红细胞的流动依赖的相互作用。这种三相血流动力学分析可能适用于体内复杂流动条件下动脉易损斑块的形成。(C)2007年，由爱思唯尔有限公司代表IPEM出版。
The behavior of blood cells in disturbed flow regions of arteries has significant relevance for understanding atherogenesis. However, their distribution with red blood cells (RBCs) and leukocytes is not so well studied and understood. Our three-phase computational fluid dynamics approach including plasma, RBCs, and leukocytes was used to numerically simulate the local hemodynamics in such a flow regime. This model has tracked the wall shear stress (WSS), phase distributions, and flow patterns for each phase in a concentrated suspension shear flow of blood. Unlike other computational approaches, this approach does not require dispersion coefficients as an input. The non-Newtonian viscosity model was applied to a wide physiological range of hematocrits, including low shear rates. The migration and segregation of blood cells in disturbed flow regions were computed, and the results compared favorably with available experimental data. The predicted higher leukocyte concentration was correlated with relatively low WSS near the stenosis having a high WSS. This behavior was attributed to flow-dependent interactions of the leukocytes with RBCs in pulsatile flow. This three-phase hemodynamic analysis may have application to vulnerable plaque formation in arteries with in vivo complex flow conditions. (c) 2007 Published by Elsevier Ltd on behalf of IPEM.