Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge
Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge
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DOI：
10.1080/03079450601113159
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发表时间：
2007-02-01
期刊：
影响因子：
2.8
通讯作者：
Sundick, R.
中科院分区：
文献类型：
--
作者：
Tarpey, I.;Davis, P. J.;Sundick, R.
随着马立克氏病病毒继续向更大的毒力进化，未来将需要更有效的疫苗。我们从火鸡疱疹病毒 (HVT) 中表达鸡白介素-2 (IL-2)，试图提高 HVT 作为马立克氏病疫苗的功效。重组 IL-2/HVT 对于卵内疫苗接种是安全的，尽管与亲本 HVT 菌株相比，它在鸟类中的复制较少。 IL-2的表达增加了针对HVT的中和抗体反应，但没有增加针对剧毒马立克氏病病毒攻击的保护作用。
As Marek's disease virus continues to evolve towards greater virulence, more efficacious vaccines will be required in the future. We expressed chicken interleukin-2 (IL-2) from a turkey herpesvirus (HVT) in an attempt to increase the efficacy of HVT as a vaccine against Marek's disease. The recombinant IL-2/HVT was safe for in ovo vaccination, although it replicated less in the birds compared with the parent HVT strain. Expression of IL-2 increased the neutralizing antibody response against HVT but did not increase the protection against virulent Marek's disease virus challenge.