Promoting health and longevity through diet: from model organisms to humans.
Promoting health and longevity through diet: from model organisms to humans.
复制标题
DOI：
10.1016/j.cell.2015.02.020
复制
发表时间：
2015-03-26
期刊：
影响因子：
64.5
通讯作者：
Partridge L
中科院分区：
文献类型：
--
作者：
Fontana L;Partridge L
减少食物摄入，避免营养不良，可以改善无脊椎动物模式生物，啮齿动物，灵长类动物和人类的衰老和衰老相关疾病。最近的研究结果表明，进餐时间是至关重要的，在总体摄入量没有变化的情况下，间歇性禁食和调整的昼夜喂养节奏都能改善健康和功能。减少特定营养素的摄入，而不是总热量的摄入，也是关键，蛋白质和特定氨基酸起着重要作用。微生物组的营养调节也很重要，饮食会产生长期影响，包括代际影响。正在确定在衰老过程中调节健康对饮食的反应的代谢、分子和细胞机制，以及对饮食反应的遗传变异。这些新的发现为特定的饮食和药物干预开辟了道路，以重新获得饮食限制的全部潜在益处，人类很难自愿保持这种益处。
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated diseases in invertebrate model organisms, rodents, primates and humans. Recent findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake. Lowered intake of particular nutrients, rather than of overall calories, is also key, with protein and specific amino acids playing prominent roles. Nutritional modulation of the microbiome can also be important, and there are long-term, including inter-generational, effects of diet. The metabolic, molecular and cellular mechanisms that mediate the responses of health during aging to diet, and genetic variation in response to diet, are being identified. These new findings are opening the way to specific dietary and pharmacological interventions to recapture the full potential benefits of dietary restriction, which humans can find hard to maintain voluntarily.