A transmission disequilibrium test for quantitative trait loci
A transmission disequilibrium test for quantitative trait loci
复制标题
DOI：
10.1159/000154433
复制
发表时间：
1997-11-01
期刊：
影响因子：
1.8
通讯作者：
Rabinowitz, D
中科院分区：
文献类型：
--
作者：
Rabinowitz, D
传递不平衡检验使用标记等位基因和二分性状之间的关联进行精确的遗传作图，同时避免由于群体混合而造成的混淆。在这里，方法是从二分性状推广到数量性状。一般化在计算上是直接的，并且可以与多个等位基因和兄弟一起使用。不需要对数量性状的分布进行参数假设。环境和人口统计学协变量可纳入分析。模拟研究的结果，提供有关的权力的方法的信息报告。
The transmission disequilibrium test uses association between marker alleles and dichotomous traits for precise genetic mapping while avoiding confounding due to population admixture. Here, the methodology is generalized from dichotomous traits to quantitative traits. The generalization is computationally straightforward and may be used with multiple alleles and with siblings. Parametric assumptions on the distribution of the quantitative traits are not needed. Environmental and demographic covariates may be incorporated into the analysis. The results of simulation studies that provide information about the power of the approach are reported.