mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors
mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors
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DOI：
10.1128/jb.180.22.6068-6071.1998
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发表时间：
1998-11-01
影响因子：
3.2
通讯作者：
Ciferri, O
中科院分区：
文献类型：
--
作者：
De Rossi, E;Branzoni, M;Ciferri, O
从结核分枝杆菌中克隆的mmr基因显示赋予耻垢分枝杆菌对四苯基磷（TPP）、红霉素、溴化乙锭、吖啶黄、番红O和派洛宁Y的抗性。该基因似乎编码含有四个跨膜结构域的蛋白质。[H-3]TPP细胞内积累的研究强烈表明，由Mmr蛋白介导的抗性涉及TPP的主动挤出。
The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [H-3]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.