TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION IN COMBINATION WITH HIGH-INTENSITY FOCUSED ULTRASOUND FOR UNRESECTABLE HEPATOCELLULAR CARCINOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS OF THE CHINESE LITERATURE
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION IN COMBINATION WITH HIGH-INTENSITY FOCUSED ULTRASOUND FOR UNRESECTABLE HEPATOCELLULAR CARCINOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS OF THE CHINESE LITERATURE
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经导管动脉化疗栓塞联合高强度聚焦超声治疗不可切除的肝细胞癌：中国文献的系统回顾和荟萃分析
DOI：
10.1016/j.ultrasmedbio.2011.03.003
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发表时间：
2011-07-01
影响因子：
2.9
通讯作者：
Li, Shao-lin
中科院分区：
文献类型：
--
作者：
Cao, Hui;Xu, Zhong;Li, Shao-lin
为了评价经导管动脉化疗栓塞术（TACE）联合高强度聚焦超声（HIFU）治疗不可切除肝细胞癌（UHCC）的疗效，我们通过检索数据库进行了系统评价和荟萃分析。在9项对照试验中，共736例患者，比较了TACE联合HIFU（A组）与单纯TACE（B组）治疗UHCC的效果。结果主要包括肿瘤缓解和生存。使用固定效应模型或随机效应模型，根据原始研究数据计算每种关系的合并优势比（OR）和95%置信区间（CI）。我们发现A组显著改善了肿瘤反应和患者的0.5年、1年、2年和3年生存率。总之，联合治疗更有益于治疗。然而，考虑到证据的强度，在常规推荐联合治疗之前，还需要额外的随机对照试验。（电子邮件：lishaolin@cqmu.edu.cn）（C）2011年世界医学和生物学超声联合会。
To evaluate the therapeutic effects of transcatheter arterial chemoembolization (TACE) in combination with high-intensity focused ultrasound (HIFU) for unresectable hepatocellular carcinoma (UHCC), we performed a systematic review and meta-analysis by searching the database. In nine controlled trials with a total of 736 patients, the effect of TACE plus HIFU (group A) was compared with TACE alone (group B) in treating UHCC. Outcomes mainly included tumor response and survival. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each relationship from raw study data using the fixed-effect model or the random effect model. We found that group A significantly improved the tumor response and 0.5-, 1-, 2-, and 3-year survival of patients. In conclusion, combined therapy was more therapeutically beneficial. However, considering the strength of the evidence, additional randomized controlled trials are needed before combined therapy can be recommended routinely. (E-mail: lishaolin@cqmu.edu.cn) (C) 2011 World Federation for Ultrasound in Medicine & Biology.