Size Controlled Synthesis of Germanium Nanocrystals by Hydride Reducing Agents and Their Biological Applications
Size Controlled Synthesis of Germanium Nanocrystals by Hydride Reducing Agents and Their Biological Applications
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DOI：
10.1021/cm9030599
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发表时间：
2010-01
影响因子：
8.6
通讯作者：
S. Prabakar;A. Shiohara;S. Hanada;K. Fujioka;Kenji Yamamoto;R. Tilley
中科院分区：
文献类型：
--
作者：
S. Prabakar;A. Shiohara;S. Hanada;K. Fujioka;Kenji Yamamoto;R. Tilley
采用氢化铝锂（LiAlH 4）、三乙基硼氢化锂（Li（C2 H5）3BH）、硼氢化锂（LiBH 4）和硼氢化钠（NaBH 4）等氢化物还原剂，在反胶束体系中还原四氯化锗（GeCl 4），合成了锗纳米晶。采用简单的室温技术制备了平均尺寸为4.0 ~ 5.5 nm的单分散Ge纳米晶。使用烯丙胺将纳米晶体封端。该纳米晶体显示出强烈的蓝色发光，并通过HepG 2细胞的成像证明了其作为光学探针的应用。采用透射电子显微镜（TEM）、选区电子衍射（SAED）、能量色散X射线光谱（EDX）和荧光光谱对纳米晶进行了表征。还报道了纳米晶体的细胞毒性，并且发现锗量子点相对无毒。
Germanium nanocrystals were synthesized by the hydride reduction of germanium tetrachloride (GeCl4) in inverse micelles using hydride reducing agents including lithium aluminum hydride (LiAlH4), lithium triethyl borohydride (Li(C2H5)3BH), lithium borohydride (LiBH4), and sodium borohydride (NaBH4). Monodisperse Ge nanocrystals with average sizes ranging from 4.0 to 5.5 nm were produced using a simple room temperature technique. The nanocrystals were capped using allylamine. The nanocrystals displayed strong blue luminescence, and their application as optical probes is demonstrated by the imaging of HepG2 cells. Transmission electron microscopy (TEM), selected area electron diffraction (SAED), energy dispersive X-ray spectroscopy (EDX), and fluorescence spectroscopy were used to characterize the nanocrystals. The cytotoxicity of the nanocrystals is also reported, and the germanium quantum dots were found to be relatively nontoxic.