Anxiety, pain, and nausea during the treatment of standard-risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group
Anxiety, pain, and nausea during the treatment of standard-risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group
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DOI：
10.1002/cncr.29876
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发表时间：
2016-04-01
期刊：
影响因子：
6.2
通讯作者：
Kadan-Lottick, Nina S.
中科院分区：
文献类型：
--
作者：
Dupuis, L. Lee;Lu, Xiaomin;Kadan-Lottick, Nina S.
本前瞻性研究描述了标准风险急性淋巴细胞白血病（ALL）儿童在治疗第一年期间经历的程序相关的焦虑，治疗相关的焦虑，疼痛和恶心。2005年至2009年，符合条件的2至9.99岁儿童入选了一项针对新诊断标准风险ALL患者的COG试验。父母在基线时完成人口统计学调查，并在诊断后1、6和12个月完成儿科生活质量量表3.0癌症模块（代理版本）和家庭评估设备的一般功能量表。评估患者相关因素（年龄、性别、种族和治疗）、父母相关因素（婚姻状况和教育）和家庭相关因素（功能、收入和大小）与症状评分之间的关系。与其他评估相比，诊断后6个月的平均恶心评分较差（P = .0085）。诊断时年龄越小，手术相关焦虑越严重（P = 0.004）。年龄较大（P = 0.0002）和分配到强化巩固研究组（P = 0.02）与恶心显著加重相关。CONCLUSIONSSALL儿童在治疗的第一年经历了治疗相关的焦虑，程序相关的焦虑和疼痛减少。与1个月和12个月的评分相比，恶心在诊断后6个月更严重。应优先考虑最大限度地减少年幼儿童与手术相关的焦虑，改善年龄较大儿童和接受更强化治疗的儿童的恶心控制。Cancer 2016;122：1116-1125. (c)2016年美国癌症协会急性淋巴细胞白血病儿童在治疗的第一年内经历治疗相关的焦虑，程序相关的焦虑和疼痛。恶心在诊断后6个月比诊断后1个月和12个月更严重。
BACKGROUNDThis prospective study describes the procedure-related anxiety, treatment-related anxiety, pain, and nausea experienced by children with standard-risk acute lymphoblastic leukemia (ALL) during the first year of treatment.METHODSThis study was undertaken at 31 Children's Oncology Group (COG) sites. Eligible children who were 2 to 9.99 years old were enrolled in a COG trial for patients with newly diagnosed standard-risk ALL from 2005 to 2009. Parents completed a demographic survey at the baseline and the Pediatric Quality of Life Inventory 3.0 Cancer Module (proxy version) and the General Functioning Scale of the Family Assessment Device 1, 6, and 12 months after the diagnosis. The association between patient-related (age, sex, ethnicity, and treatment), parent-related (marital status and education), and family-related factors (functioning, income, and size) and symptom scores was evaluated.RESULTSThe mean scores for procedure-related anxiety, treatment-related anxiety, and pain improved during the first year of treatment (P < .0389). The mean nausea score was poorer 6 months after the diagnosis in comparison with the other assessments (P = .0085). A younger age at diagnosis was associated with significantly worse procedure-related anxiety (P = .004). An older age (P = .0002) and assignment to the intensified consolidation study arm (P = .02) were associated with significantly worse nausea.CONCLUSIONSChildren with ALL experienced decreasing treatment-related anxiety, procedure-related anxiety, and pain during the first year of treatment. In comparison with scores at 1 and 12 months, nausea was worse 6 months after the diagnosis. Minimization of procedure-related anxiety in younger children and improved nausea control in older children and those receiving more intensified treatment should be prioritized. Cancer 2016;122:1116-1125. (c) 2016 American Cancer Society Children with acute lymphoblastic leukemia experience decreasing treatment-related anxiety, procedure-related anxiety, and pain over the first year of treatment. Nausea is worse 6 months after the diagnosis in comparison with 1 and 12 months after the diagnosis.