Integration of visual and non-visual self-motion cues during voluntary head movements in the human brain
Integration of visual and non-visual self-motion cues during voluntary head movements in the human brain
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DOI：
10.1016/j.neuroimage.2018.02.006
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发表时间：
2018-05
期刊：
影响因子：
5.7
通讯作者：
A. Schindler;A. Bartels
中科院分区：
文献类型：
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作者：
A. Schindler;A. Bartels
我们对稳定世界的现象学体验是通过视觉自我运动与视网膜外信号的持续整合来维持的。然而，由于传统的限制，在人类的功能磁共振成像采集，视觉前庭整合的神经反应只研究了使用人工刺激，在没有自愿的头部运动。我们在这里绕过了这些限制，让参与者在扫描过程中移动他们的头部。BOLD信号的缓慢动态使我们能够在观察者的头部通过充气气垫稳定后获得与头部运动相关的神经信号。视觉刺激呈现在固定在头部的显示护目镜上，并根据使用外部摄像头跟踪的头部运动进行真实的更新。两种情况模拟了参与者的向前平移。在物理头部旋转过程中，一致条件模拟了一个稳定的世界，而不一致条件增加了任意的横向运动。重要的是，这两种情况在视觉特性和头部旋转方面精确匹配。通过比较一致与不一致的条件下，我们发现的证据一致的多模态整合的视觉线索与头部运动到一个连贯的“稳定的世界”的顶叶盖和顶叶岛叶皮层（aPIC）的前部的接受。在视觉运动网络中，人类的MST区域、VIP背侧部分、扣带回视区（CSV）和楔前叶区域（Pc）对相同的对比度表现出不同的反应。结果表明，第一次精确匹配的一致与不一致的视觉和非视觉线索之间的神经多模态相互作用在人类大脑的物理头部运动。方法学的方法开辟了一个新的类的功能磁共振成像研究前所未有的时间和空间控制视觉前庭刺激的道路。
Our phenomenological experience of the stable world is maintained by continuous integration of visual self-motion with extra-retinal signals. However, due to conventional constraints of fMRI acquisition in humans, neural responses to visuo-vestibular integration have only been studied using artificial stimuli, in the absence of voluntary head-motion. We here circumvented these limitations and let participants to move their heads during scanning. The slow dynamics of the BOLD signal allowed us to acquire neural signal related to head motion after the observer's head was stabilized by inflatable aircushions. Visual stimuli were presented on head-fixed display goggles and updated in real time as a function of head-motion that was tracked using an external camera. Two conditions simulated forward translation of the participant. During physical head rotation, the congruent condition simulated a stable world, whereas the incongruent condition added arbitrary lateral motion. Importantly, both conditions were precisely matched in visual properties and head-rotation. By comparing congruent with incongruent conditions we found evidence consistent with the multi-modal integration of visual cues with head motion into a coherent “stable world” percept in the parietal operculum and in an anterior part of parieto-insular cortex (aPIC). In the visual motion network, human regions MST, a dorsal part of VIP, the cingulate sulcus visual area (CSv) and a region in precuneus (Pc) showed differential responses to the same contrast. The results demonstrate for the first time neural multimodal interactions between precisely matched congruent versus incongruent visual and non-visual cues during physical head-movement in the human brain. The methodological approach opens the path to a new class of fMRI studies with unprecedented temporal and spatial control over visuo-vestibular stimulation.