Assessment of Liver Viscoelasticity by Using Shear Waves Induced by Ultrasound Radiation Force
Assessment of Liver Viscoelasticity by Using Shear Waves Induced by Ultrasound Radiation Force
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DOI：
10.1148/radiol.12120837
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发表时间：
2013-03-01
期刊：
影响因子：
19.7
通讯作者：
Metz, Stephen
中科院分区：
文献类型：
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作者：
Chen, Shigao;Sanchez, William;Metz, Stephen
目的：探讨超声弹性成像（US）测量粘度在肝纤维化分期中的价值，并探讨用粘弹性模型估计肝弹性是否能提高其在肝纤维化分期中的准确性。材料和方法：本研究于2010年2月至2011年3月进行，符合HIPAA，并经机构审查委员会批准。获得每位受试者的书面知情同意书。10名健康志愿者（8名女性和2名男性，年龄27-55岁）和35名肝病患者（17名女性和18名男性，年龄19-74岁）通过使用美国肝脏弹性测量（肝活检后6个月内）进行研究。采用剪切波色散超声振动测量（SDUV）方法对美国数据进行分析，其中通过评估剪切波传播速度的色散来测量弹性和粘度，以及采用峰值时间（TTP）方法，其中忽略组织粘度，仅从有效剪切波速估计弹性。采用METAVIR评分系统对肝纤维化分期进行组织学评估。用Pearson相关系数评价弹性和粘度的相关性。采用受试者工作特征（ROC）曲线分析评价SDUV和TTP的性能。结果：作者发现SDUV测量的弹性和粘度（r = 0.80）与SDUV和TTP测量的弹性（r = 0.94）具有显著相关性。区分F0-F1级纤维化和F2-F4级纤维化的ROC曲线下面积，用SDUV测量弹性为0.98，用SDUV测量粘度为0.86，用TTP测量弹性为0.95。结论：结果表明，使用SDUV在95 Hz和380 Hz之间测量的弹性和粘度是相关的，并且SDUV和TTP的弹性测量在肝纤维化分期中显示出基本相似的性能，尽管SDUV计算的弹性在ROC曲线下提供了更好的面积。(c) rsna, 2012
Purpose: To investigate the value of viscosity measured with ultrasonographic (US) elastography in liver fibrosis staging and to determine whether the use of a viscoelastic model to estimate liver elasticity can improve its accuracy in fibrosis staging.Materials and Methods: The study, which was performed from February 2010 to March 2011, was compliant with HIPAA and approved by the institutional review board. Written informed consent was obtained from each subject. Ten healthy volunteers (eight women and two men aged 27-55 years) and 35 patients with liver disease (17 women and 18 men aged 19-74 years) were studied by using US elasticity measurements of the liver (within 6 months of liver biopsy). US data were analyzed with the shear wave dispersion ultrasound vibrometry (SDUV) method, in which elasticity and viscosity are measured by evaluating dispersion of shear wave propagation speed, as well as with the time-to-peak (TTP) method, where tissue viscosity was neglected and only elasticity was estimated from the effective shear wave speed. The hepatic fibrosis stage was assessed histologically by using the METAVIR scoring system. The correlation of elasticity and viscosity was assessed with the Pearson correlation coefficient. The performances of SDUV and TTP were evaluated with receiver operating characteristic (ROC) curve analysis.Results: The authors found significant correlations between elasticity and viscosity measured with SDUV (r = 0.80) and elasticity measured with SDUV and TTP (r = 0.94). The area under the ROC curve for differentiating between grade F0-F1 fibrosis and grade F2-F4 fibrosis was 0.98 for elasticity measured with SDUV, 0.86 for viscosity measured with SDUV, and 0.95 for elasticity measured with TTP.Conclusion: The results suggest that elasticity and viscosity measured between 95 Hz and 380 Hz by using SDUV are correlated and that elasticity measurements from SDUV and TTP showed substantially similar performance in liver fibrosis staging, although elasticity calculated from SDUV provided a better area under the ROC curve. (C) RSNA, 2012