Insights from American College of Allergy, Asthma, and Immunology COVID-19 Vaccine Task Force: Allergic Reactions to mRNA SARS-CoV-2 Vaccines.
Insights from American College of Allergy, Asthma, and Immunology COVID-19 Vaccine Task Force: Allergic Reactions to mRNA SARS-CoV-2 Vaccines.
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DOI：
10.1016/j.anai.2021.01.017
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Blaiss MS
中科院分区：
文献类型：
--
作者：
Murphy KR;Patel NC;Ein D;Hudelson M;Kodoth S;Marshall GD Jr;Parikh P;Blaiss MS
一般来说，对疫苗的过敏反应是罕见的，过敏反应的发生率估计为1.31/100万剂。1近期，辉瑞BioNTech和Moderna针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的mRNA疫苗接种者发生了临床上与过敏反应相容的速发型过敏反应。目前，其具体机制和诱发抗原/因子尚未确定。2021年1月6日的《发病率和死亡率周报》2总结了2020年12月14日至2020年12月23日在美国接种首剂辉瑞-BioNTech 2019冠状病毒病（COVID-19）疫苗后报告的过敏反应（包括过敏反应）。在此期间，疫苗不良事件报告系统的监测发现了21起被确定为过敏反应的不良事件，据报道，辉瑞-BioNTech COVID-19疫苗的第一剂接种量为1，893，360剂（每百万剂11.1例）;其中71%发生在接种疫苗后15分钟内。疾病控制和预防中心（CDC）建议，2疫苗不应给予已知对疫苗任何成分有严重过敏反应史的个体。3虽然引起过敏反应的特定疫苗成分尚未确定，但聚乙二醇（PEG）是其中一种成分，已知在其他临床环境中会引起过敏反应。目前，没有其他疫苗使用PEG 2000，这是两种mRNA CoV-2疫苗的疫苗组分。此外，聚山梨醇酯，一种在药物和食品中发现的赋形剂，可以与PEG发生交叉反应。因此，对聚山梨酯有过敏反应的患者不应接种mRNA疫苗。
Allergic reactions to vaccines, in general, are rare, with the incidence of anaphylaxis estimated at 1.31 in 1 million doses given. 1 Recent immediate allergic reactions clinically compatible with anaphylaxis have occurred in recipients of both the Pfizer-BioNTech and Moderna mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, the specific mechanisms and inciting antigen/agents have not been identified. The January 6, 2021, Morbidity and Mortality Weekly Report2 summarized the reported allergic reactions (including anaphylaxis) after receipt of the first dose of Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine in the United States from December 14, 2020, to December 23, 2020. During that period, monitoring by the Vaccine Adverse Event Reporting System detected 21 adverse events identified as anaphylaxis after administration of a reported 1,893,360 first doses of the Pfizer-BioNTech COVID-19 vaccine (11.1 cases per million doses); 71% of these occurred within 15 minutes of vaccination.The Centers for Disease Control and Prevention (CDC) has recommended that the mRNA SARS-CoV-2 vaccines should not be administered to individuals with a known history of a severe allergic reaction to any component of the vaccine. 3 Although the specific vaccine component causing anaphylaxis has not been identified, polyethylene glycol (PEG) is one of the ingredients and has been known to cause anaphylaxis in other clinical settings. At present, there are no other vaccines that use PEG 2000, the vaccine component for both mRNA CoV-2 vaccines. In addition, polysorbate, an excipient found in medications and foods, can crossreact with PEG. Accordingly, patients with documented allergic reactions to polysorbate should not be immunized with the mRNA vaccines.
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影响因子：
14.2
作者：
Kelso, John M.;Greenhawt, Matthew J.;Wallace, Dana
通讯作者：
Wallace, Dana
影响因子：
14.2
作者：
McNeil, Michael M.;Weintraub, Eric S.;DeStefano, Frank
通讯作者：
DeStefano, Frank
DOI：
10.1016/j.jaip.2020.12.047
发表时间：
2021-04
期刊：
The journal of allergy and clinical immunology. In practice
影响因子：
--
作者：
Banerji A;Wickner PG;Saff R;Stone CA Jr;Robinson LB;Long AA;Wolfson AR;Williams P;Khan DA;Phillips E;Blumenthal KG
通讯作者：
Blumenthal KG
DOI：
10.15585/mmwr.mm7004e1externalicon
发表时间：
2021-01-15
影响因子：
33.9
作者：
Shimabukuro, Tom
通讯作者：
Shimabukuro, Tom