Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein
Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein
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DOI：
10.1016/s0014-5793(02)02694-7
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发表时间：
2002-05-08
期刊：
影响因子：
3.5
通讯作者：
Jang, KL
中科院分区：
文献类型：
--
作者：
Han, HJ;Jung, EY;Jang, KL
B型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的共感染是常见的，并且与更严重的肝脏疾病和肝细胞癌（HCC）的发生频率增加相关。在这里，我们证明了HBV X蛋白（HBx）和HCV核心蛋白在转录水平上叠加抑制通用细胞周期蛋白依赖性激酶抑制剂p21基因。p21启动子的Sp1位点和转化生长因子-P反应元件分别负责HCV核心和HBx的作用。此外，细胞生长被它们相加刺激，这表明p21的相加抑制对于理解HBV和HCV在HCC中的协同发展可能是重要的。(C)2002年由Elsevier Science B. V.代表欧洲生物化学学会联合会出版。
Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is common and is associated with a more severe liver disease and increased frequency in the development of hepatocellular carcinoma (HCC). Here, we demonstrated that HBV X protein (HBx) and HCV core protein additively repress the universal cyclin-dependent kinase inhibitor p21 gene at the transcription level. The transforming growth factor-P responsive element and Sp1 site of the p21 promoter were responsible for the effect of HCV core and HBx, respectively. Furthermore, cell growth was additively stimulated by them, suggesting that additive repression of the p21 might be important to understand the cooperative development of HCC by HBV and HCV. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.