A pilot study of exercise training to reduce trunk fat in adults with HIV-associated fat redistribution.
A pilot study of exercise training to reduce trunk fat in adults with HIV-associated fat redistribution.
复制标题
一项运动训练试点研究，旨在减少患有艾滋病毒相关脂肪重新分布的成年人的躯干脂肪。
DOI：
10.1097/00002030-199907300-00015
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Gorbach,S
中科院分区：
文献类型：
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作者：
Roubenoff,R;Weiss,L;McDermott,A;Heflin,T;Cloutier,GJ;Wood,M;Gorbach,S
目的：身体脂肪再分布（“脂肪营养不良”），腹部和躯干脂肪增加，面部和四肢脂肪减少，是HIV感染患者中新认识到的问题，与HIV-1蛋白酶抑制剂的使用有关。腹部脂肪增加可能使这些患者易患高血压、糖尿病和冠状动脉疾病。目前尚无有效的治疗方法。我们研究了运动训练是否可以减少躯干脂肪的男子与fatredistribution.Design：Open-label pilot study.Methods：10名男子增加腹围参加了为期16周的试点研究渐进式阻力训练与有氧成分。他们每周在社区健康俱乐部训练三次。通过双能X射线吸收法（DXA）评估全身瘦体重和脂肪量以及躯干脂肪量。结果：经过16周的锻炼，四种运动中有三种的力量增加（腿部推举+ 13%[p< 0.02]，腿部伸展+ 19%[p< 0.03]，坐行+ 7%[p< 0.13]，胸部推举+ 18%[p< 0.005]）。总体脂显著下降1.5 kg（= 2.1个百分点，p< 0.01）;体脂下降的大部分发生在躯干脂肪，减少了1.1 kg（p< 0.03）。体重、瘦体重（+ 1.1±2.6 kg，p= 0.23）和DXA测量的骨矿物质密度没有变化。从training.Conclusions：运动训练可以减少躯干脂肪量的HIV阳性男性脂肪再分布。这种方法的控制试验是必要的。
Objective:Body fat redistribution (‚lipodystrophy ‚), with gain in abdominal and trunk fat, and decline in facial and limb fat, is a newly recognized problem in patients with HIV infection that has been linked to use of HIV-1 protease inhibitors. Increased abdominal fat may predispose these patients to hypertension, diabetes, and coronary artery disease. At this time no effective treatment is available. We examined whether exercise training could reduce trunk fat in men with fat redistribution.Design:Open-label pilot study.Methods:Ten men with increasing abdominal girth participated in a 16 week pilot study of progressive resistance training with an aerobic component. They trained in a community health club three times per week. Total body lean and fat mass, and trunk fat mass, were assessed by dual-energy x-ray absorptiometry (DXA).Results:After 16 weeks of exercise, strength increased for three of the four exercises tested (leg press+ 13%[p< 0.02], leg extension+ 19%[p< 0.03], seated row+ 7%[p< 0.13], chest press+ 18%[p< 0.005]). There was a significant decline in total body fat by 1.5 kg (= 2.1 percentage points, p< 0.01); most of the decline in body fat occurred in trunk fat, which decreased by 1.1 kg (p< 0.03). Weight, lean mass (+ 1.1±2.6 kg, p= 0.23), and bone mineral density measured by DXA did not change. No adverse effects were seen from the training.Conclusions:Exercise training may reduce trunk fat mass in HIV-positive men with fat redistribution. Controls trials of this approach are warranted.