Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia.
Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia.
复制标题
通过光学相干断层扫描检测黄斑中心凹发育不全眼的外视网膜畸形。
DOI：
10.1007/s00417-016-3385-z
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Azuma N.
中科院分区：
文献类型：
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作者：
Katagiri S;Yokoi T;Mikami M;Nishina S;Azuma N.
目的探讨视力与黄斑中心凹成熟度的关系，特别是黄斑中心凹发育不全的严重结构性不成熟。方法回顾性观察23例（平均年龄7.0 ± 5.0岁，9例黄斑中心凹发育不全为独立个体，14例无虹膜）42只眼。完整的眼科检查包括最佳矫正视力（BCVA）和光谱域光学相干断层扫描（SD-OCT）的测量。感觉视网膜，神经节细胞复合体（GCC），和视网膜外层，包括汉勒氏纤维层（HFL），进行了测量和analysed.ResultsUsing SD-OCT图像，眼睛被分类为具有分化（6只眼），弥漫性（19只眼），或没有HFL（17只眼），根据周围的中心凹区域的HFL的外观。弥漫性HFL眼和无HFL眼的logMAR BCVA显著差于分化型HFL眼（p< 0.0001）。外视网膜厚度（外丛状层+ HFL +外核层）在没有HFL的眼睛中小于（p= 0.0051）分化HFL的眼睛。中心凹发育不全伴无虹膜的眼的logMAR BCVA、GCC厚度和外视网膜厚度显著更差（p= 0.0083），较厚（p= 0.0039），并且更瘦（p= 0.0001），分别比作为一个孤立实体的中心凹发育不全的眼睛。弥漫性HFL或无HFL与视力下降相关。与单独的中心凹发育不全相比，中心凹发育不全伴无虹膜的眼睛的中心凹不成熟程度更高。
PurposeTo investigate the relationship between vision and foveal maturity, especially in foveal hypoplasia exhibiting severe structural immaturity.MethodsThis retrospective observational case series included 42 eyes of 23 patients (mean age, 7.0 ± 5.0 years; 9 patients with foveal hypoplasia as an isolated entity and 14 patients with aniridia). A complete ophthalmic examination included measurement of best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT). The sensory retina, ganglion cell complex (GCC), and outer retinal layers, including Henle’s fiber layer (HFL), were measured and analyzed.ResultsUsing SD-OCT images, eyes were classified as having a differentiated (6 eyes), diffuse (19 eyes), or no HFL (17 eyes), based on the appearance of the HFL around the foveal region. The logMAR BCVA was significantly worse (p< 0.0001) in eyes with diffuse HFL and those with no HFL than in those with differentiated HFL. Outer retinal thickness (outer plexiform layer + HFL + outer nuclear layer) was less (p= 0.0051) in eyes with no HFL than in those with differentiated HFL. The logMAR BCVA, GCC thickness, and outer retinal thickness in eyes with foveal hypoplasia with aniridia were significantly worse (p= 0.0083), thicker (p= 0.0039), and thinner (p= 0.0001), respectively, than in eyes with foveal hypoplasia as an isolated entity.ConclusionsIn eyes with foveal hypoplasia with severe structural immaturity, diffuse HFL or no HFL was associated with worse vision. There was greater foveal immaturity in eyes with foveal hypoplasia with aniridia compared with foveal hypoplasia as an isolated entity.