Herpes simplex virus type 2 associated with HIV infection among New York heterosexuals living in high-risk areas.
Herpes simplex virus type 2 associated with HIV infection among New York heterosexuals living in high-risk areas.
复制标题
DOI：
10.1258/ijsa.2010.010137
复制
发表时间：
2010-08
影响因子：
1.4
通讯作者：
Gelpi-Acosta C
中科院分区：
文献类型：
--
作者：
Hagan H;Jenness SM;Wendel T;Murrill CR;Neaigus A;Gelpi-Acosta C
单纯疱疹病毒2型（HSV-2）已被证明会增加性传播人类免疫缺陷病毒（HIV）的风险。采用匹配病例对照设计研究了纽约市“高危地区”异性恋者中HSV-2与HIV感染之间的关系。我们利用异性恋相关成人HIV诊断的HIV监测数据和美国家庭贫困人口普查数据确定纽约市hra。在社会上或地理上与HRA有联系的异性恋者采用受访者驱动的抽样方法被招募。HIV患病率为8.6%，HSV-2患病率为80.1%。只有6%的hiv阳性患者知道自己被感染了。hiv阳性病例与hiv阴性对照在性别、种族/民族和年龄上进行匹配，并进行HSV-2抗体检测。在一个多变量模型中，HIV感染与前一年的HSV-2感染（调整优势比[AOR] = 3.5, 95%置信区间为1.1-11.7）和非hsv相关的性传播感染诊断相关（AOR = 2.6, 1.1-6.2）。减少2型单纯疱疹病毒感染者艾滋病毒风险的有效方法仍然不确定，而在促进艾滋病毒感染的多种社会、行为和生物因素并存的高风险社区，迫切需要这些方法。
Herpes simplex virus type 2 (HSV-2) has been shown to increase the risk of sexual human immunodeficiency virus (HIV) transmission. A matched case-control design was used to examine the association between HSV-2 and HIV infection among heterosexuals in ‘high-risk areas’ (HRAs) in New York City (NYC). We identified NYC HRAs using HIV surveillance data on heterosexual-related adult HIV diagnoses and USA census data on household poverty. Heterosexuals who were socially or geographically linked to an HRA were recruited using respondent-driven sampling. HIV prevalence was 8.6% and HSV-2 prevalence was 80.1%. Only 6% of HIV-positives knew they were infected. HIV-positive cases were matched to HIV-negative controls on gender, race/ethnicity and age, and tested for antibody to HSV-2. In a multivariate model, HIV infection was associated with HSV-2 infection (adjusted odds ratio [AOR] = 3.5, 95% confidence interval 1.1–11.7) and non-HSV-related sexually transmitted infection diagnosis in the previous year (AOR = 2.6, 1.1–6.2). Effective approaches to HIV risk reduction for individuals with HSV-2 remain uncertain, and these are urgently needed in high-risk communities where multiple social, behavioural and biological factors that facilitate HIV infection coexist.