Fetal death persists through recurrent pregnancies in mice following Ljungan virus infection.
Fetal death persists through recurrent pregnancies in mice following Ljungan virus infection.
复制标题
小鼠感染永甘病毒后反复怀孕，胎儿死亡现象持续存在。
DOI：
10.1002/bdrb.20169
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Klitz,William
中科院分区：
文献类型：
--
作者：
Samsioe,Annika;Sjöholm,Ake;Niklasson,Bo;Klitz,William
目的：实验小鼠在妊娠早期感染Ljugan病毒(Ljugan Virus，LV)，造成围产儿死亡。在这里，我们通过LV感染的小鼠连续怀孕的结局来研究这种影响的持久性。STUDY设计：CD-1小鼠在怀孕期间被感染，其成年雌性后代在重复怀孕期间与未感染的对照小鼠并行跟踪。三次交配尝试导致每只母鹿怀孕两到三次。结果：成年感染的母鼠及其成年雌性后代在最后一次妊娠期间均发生围产儿死亡，发生在首次LV暴露和急性感染后约6个月。未感染的对照动物没有围产期死亡。结论：在这种LV感染的小鼠模型中，无论是成年感染的动物还是在子宫中暴露于病毒的雌性动物，围产期死亡都会持续到反复怀孕期间。这意味着LV在初始感染后在小鼠体内持续很长时间，并保持在静止状态，但在以后的怀孕中仍可保持致病性。出生缺陷资源(B部分)83：507-510,2008。©2008 Wiley-Liss，Inc.
OBJECTIVES:Laboratory mice infected with Ljungan virus (LV) early in pregnancy suffer from perinatal death. Here we investigate the persistence of that effect through the outcome of consecutive pregnancies in LV‐infected mice.STUDY DESIGN:CD‐1 mice were infected while pregnant and their adult female offspring were followed in parallel with uninfected control mice during repeated pregnancies. Three mating attempts resulted in two or three pregnancies per dam. The outcome of the last pregnancy was carefully monitored.RESULTS:Both the dams infected as adults and their adult female offspring suffered perinatal deaths during the last pregnancy which occurred approximately 6 months after the original LV exposure and acute infection. The non‐infected control animals experienced no perinatal death.CONCLUSIONS:Perinatal death persists across recurrent pregnancies in this mouse model of LV infection, both in animals infected as adults and in females exposed to the virus in utero. This implies that LV persists in mice long after intial infection, and is maintained in a quiescent state but can remain pathogenic in later pregnancies.Birth Defects Res (Part B)83:507‐510, 2008. © 2008 Wiley‐Liss, Inc.