Active ghrelin and the postpartum.
Active ghrelin and the postpartum.
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DOI：
10.1007/s00737-015-0578-0
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Brownley KA
中科院分区：
文献类型：
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作者：
Baker JH;Pedersen C;Leserman J;Brownley KA
产后抑郁症（PPD）发生在10%-15%的妇女。食欲激素ghrelin在怀孕期间波动，与非怀孕样本中的抑郁症有关。在这里，我们研究PPD和积极ghrelin从怀孕到产后之间的关联。我们还研究了生长激素释放肽是否从怀孕到产后的变化，以及母乳喂养和非母乳喂养妇女之间的差异。60名妇女参加了一项检查PPD的调查，并在研究中纳入了关于ghrelin浓度的信息。爱丁堡产后抑郁量表被用来评估PPD的症状。原始生长激素释放肽水平和经肌酐校正的生长激素释放肽水平作为结局。产后12周PPD筛查阳性的妇女有较高的妊娠生长激素释放肽浓度。生长激素释放肽浓度显着下降，从怀孕到产后6周，这种变化不同的基础上怀孕抑郁状态。最后，母乳喂养的女性的胃饥饿素水平低于奶瓶喂养的女性。一旦根据肌酸酐调整ghrelin水平，则无显著发现。虽然结果并不表明调整肌酐后PPD和ghrelin之间的关联，但未来的研究应继续探索这种可能性，进一步扩大产后期间的样本量。
Postpartum depression (PPD) occurs in 10%–15% of women. The appetite hormone ghrelin, which fluctuates during pregnancy, is associated with depression in nonpregnant samples. Here, we examine the association between PPD and active ghrelin from pregnancy to postpartum. We additionally examine whether ghrelin changes from pregnancy to postpartum and differs between breastfeeding and non-breastfeeding women. Sixty women participated in a survey examining PPD and had information in regard to ghrelin concentrations were included in the study. The Edinburgh Postnatal Depression Scale was used to assess symptoms of PPD. Raw ghrelin levels and ghrelin levels adjusted for creatinine were included as outcomes. Women screening positive for PPD at 12-weeks postpartum had higher pregnancy ghrelin concentrations. Ghrelin concentrations significantly decreased from pregnancy to 6-weeks postpartum and this change differed based on pregnancy depression status. Finally, ghrelin levels were lower in women who breastfed compared with women who were bottle-feeding. No significant findings remained once ghrelin levels were adjusted for creatinine. Although results do not suggest an association between PPD and ghrelin after adjusting for creatinine, future research should continue to explore this possibility extending further across the postpartum period with larger sample sizes.