Association of hypometabolism and amyloid levels in aging, normal subjects
Association of hypometabolism and amyloid levels in aging, normal subjects
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DOI：
10.1212/wnl.0000000000000467
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发表时间：
2014-06-03
期刊：
影响因子：
9.9
通讯作者：
Petersen, Ronald C.
中科院分区：
文献类型：
--
作者：
Lowe, Val J.;Weigand, Stephen D.;Petersen, Ronald C.
目的：我们评估了淀粉样蛋白的关系，看到匹兹堡化合物B（PiB）-PET，和代谢，看到[F-18]-氟脱氧葡萄糖（FDG）-PET，在正常subjects中，以更好地了解发病机制和生物标志物的选择在症状前subjects.Methods：正常参与者（年龄70-95岁，600 PiB-PET，FDG-PET和MRI）。我们进行了一项横断面评估，并将参与者分为淀粉样蛋白阴性（
Objective: We evaluated the relationship of amyloid, seen on Pittsburgh compound B (PiB)-PET, and metabolism, seen on [F-18]-fluorodeoxyglucose (FDG)-PET, in normal subjects to better understand pathogenesis and biomarker selection in presymptomatic subjects.Methods: Normal participants (aged 70-95 years; 600 with PiB-PET, FDG-PET, and MRI) were included. We performed a cross-sectional evaluation and subcategorized participants into amyloid-negative (