Polyomavirus BK-specific immunity after kidney transplantation
Polyomavirus BK-specific immunity after kidney transplantation
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DOI：
10.1097/01.tp.0000137932.44791.d3
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发表时间：
2004-10-27
期刊：
影响因子：
6.2
通讯作者：
Ginevri, F
中科院分区：
文献类型：
--
作者：
Comoli, P;Azzi, A;Ginevri, F
未能建立或维持保护性免疫应答可能会影响多瘤病毒BK（BKV）相关肾病（PVAN）的发展。然而，有限的数据是迄今为止，肾移植后BKV特异性免疫。通过测量外周血中干扰素（IFN）-γ分泌细胞的频率，回顾性分析了有或无BKV感染/再活化的肾受体中BKV特异性细胞免疫应答。BKV活动性感染和肾功能良好的患者（n=6）的平均BKV特异性淋巴细胞频率比健康对照组低2 log，与无活动性感染的BKV血清阳性受者（n=7）的范围相同。PVAN患者（n=5）显示BKV特异性细胞水平不可检测。然而，来自后一队列的两名接受免疫抑制减少治疗的患者显示特异性免疫的出现，IFN-γ的产生与健康对照在相同的范围内。我们的初步数据表明，缺乏对BKV的保护性免疫可能有利于BKV活动性感染的发生，并影响PVAN的进展。
Failure to mount or maintain a protective immune response may influence the development of polyomavirus BK (BKV)-associated nephropathy (PVAN). However, limited data are so far available on BKV-specific immunity after kidney transplantation. BKV-specific cellular immune response was retrospectively analyzed in kidney recipients with or without BKV infection/reactivation by measuring the frequency of interferon (IFN)-gamma-secreting cells in peripheral blood. Patients with BKV-active infection and good renal function (n=6) had a mean BKV-specific lymphocyte frequency 2 log lower than healthy controls and in the same range as BKV-seropositive recipients without active infection (n=7). Patients with PVAN (n=5) revealed undetectable levels of BKV-specific cells. However, two patients from the latter cohort treated with immunosuppression reduction showed the emergence of specific immunity, with IFN-gamma production in the same range as healthy controls. Our preliminary data suggest that lack of protective immunity toward BKV may favor the occurrence of BKV active infection and influence the progression to PVAN.