Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination.
Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination.
复制标题
DOI：
10.1002/glia.22297
复制
发表时间：
2012-04
期刊：
影响因子：
6.2
通讯作者：
Bethea, John R.
中科院分区：
文献类型：
--
作者：
Morton, Paul D.;Johnstone, Joshua T.;Ramos, Angel Y.;Liebl, Daniel J.;Bunge, Mary Bartlett;Bethea, John R.
雪旺细胞（SC）对周围神经发育和再生至关重要;然而，对损伤后反应的内在调控机制知之甚少。核因子-κB（NF- κB）的活化和去乙酰化是周围神经髓鞘形成的先决条件。使用GFAP-IκBα-dn小鼠，其中NF- κB转录激活在SC中被抑制，我们发现成年面神经中有髓鞘轴突的数量或结构没有明显差异。挤压损伤后，转基因动物的轴突再生在31天受损，在65天显著增强。致密的髓鞘再生和Remak束组织在损伤后31天显著受损，并在损伤后65天恢复。总之，这些数据表明，抑制SC中NF- κB活化可短暂延迟轴突再生和致密髓鞘形成。操纵雪旺细胞中核因子-κB的时间激活可能为PNS和CNS再生提供新的治疗途径。
Schwann cells (SCs) are crucial for peripheral nerve development and regeneration; however, the intrinsic regulatory mechanisms governing post-injury responses are poorly understood. Activation and deacetylation of nuclear factor-κB (NF- κB) in SCs have been implicated as prerequisites for peripheral nerve myelination. Using GFAP-IκBα-dn mice in which NF- κB transcriptional activation is inhibited in SCs we found no discernable differences in the quantity or structure of myelinated axons in adult facial nerves. Following crush injury, axonal regeneration was impaired at 31 days and significantly enhanced at 65 days in transgenic animals. Compact re-myelination and Remak bundle organization were significantly compromised at 31 days and restored by 65 days post injury. Together, these data indicate that inhibition of NF- κB activation in SCs transiently delays axonal regeneration and compact re-myelination. Manipulating the temporal activation of nuclear factor-κB in Schwann cells may offer new therapeutic avenues for PNS and CNS regeneration.
登录
查看更多内容
影响因子：
15.3
作者：
Brambilla, R;Bracchi-Ricard, V;Hu, WH;Frydel, B;Bramwell, A;Karmally, S;Green, EJ;Bethea, JR
通讯作者：
Bethea, JR
影响因子：
7.4
作者：
Fu ES;Zhang YP;Sagen J;Candiotti KA;Morton PD;Liebl DJ;Bethea JR;Brambilla R
通讯作者：
Brambilla R
影响因子：
5.8
作者：
Miller, Susanne C.;Huang, Ruili;Sakamuru, Srilatha;Shukla, Sunita J.;Attene-Ramos, Matias S.;Shinn, Paul;Van Leer, Danielle;Leister, William;Austin, Christopher P.;Xia, Menghang
通讯作者：
Xia, Menghang
影响因子：
4.7
作者：
Brambilla R;Hurtado A;Persaud T;Esham K;Pearse DD;Oudega M;Bethea JR
通讯作者：
Bethea JR
影响因子：
25
作者：
Nickols, JC;Valentine, W;Carter, BD
通讯作者：
Carter, BD